Tissue Engineering and Regenerative Medicine: Curriculum

Here you'll find detailed information on current courses of the Master's degree program Tissue Engineering and Regenerative Medicine. Please note that due to ongoing updates not all courses of the program might be fully displayed. A complete overview of the curriculum for the study year 2016/17 is going to be published in the course of the summer semester 2016.

1. Semester

Name ECTS
SWS
Economic and Legal Issues and Professional Communication 1 (kM12)
English / kMod
4.00
-
Advanced English (ADE)
English / SE
1.00
1.00

Course description

We aim at conveying the language-related criteria and techniques required for leading and participating in discussions and writing a summary on current issues and topics in the Cell and Tissue Engineering profession

Methodology

Seminar

Learning outcomes

After passing this course successfully students are able to ...

  • lead a professional discussion in English, i.e. to apply appropriate language and techniques for effective research, formulation of questions, moderation, summarizing etc.;
  • write a summary of the facts and main arguments of relevant topics

Course contents

  • Language and techniques for leading a professional discussion
  • Defining, researching, presenting, and leading a discussion on an appropriate professional topic
  • Vocabulary work-up based on research sources for the discussion topic
  • Writing a summary of the main facts and arguments pertaining to the discussion topic

Prerequisites

Common European Framework of Reference for Languages Level B2

Literature

  • Göschka, M. et al. (2014) Guidelines for Scientific Writing, Skriptum
  • Harvard Business Review 20-Minute Manager Series: Running Meetings
  • Additional current handouts

Assessment methods

  • active participation in class activities and timely completion of assignments
Corporate Management (COM)
English / SE
2.00
2.00

Course description

The course shall provide an overview over the essential elements of Management in order to prepare the students for managerial tasks in practical business life. After an introduction to basics of management (managers, environment, social responsibility) the course covers the 4 managerial steps Planning, Organizing, Leading and Control. Practical examples focus particularly on the pharmaceutical industry.

Methodology

Lectures with Powerpoint Slides as well as discussions and several case studies.

Learning outcomes

After passing this course successfully students are able to ...

  • define tasks and steps of the managerial process for companies as well as explain examples for “effective” and “efficient” management
  • analyze the economic situation of a company as a manager, for example by using comparative data in income statements
  • develop and define company goals as a manager
  • make decisions as a manager as well as to explain and justify them
  • recognize critical situations in terms of business ethics and develop solutions
  • explain methods how to motivate employees and evaluate their applicability in practical cases
  • evaluate various methods of communication for practical management
  • explain leadership styles and their advantages and disadvantages for specific situations and persons

Course contents

  • Basics of management, decision making in business, planning, organizational structure and culture, change management, time management, managing teams, motivation of employees, leadership traits and styles, communication in business, controlling, key factors of successful management

Literature

  • Stephen P. Robbins, David A. DeCenzo, Mary CoulterFundamentals of ManagementPearson Education, 2014, 9th Global EditionISBN-10: 1292056541ISBN-13: 978-1292056548

Assessment methods

  • End exam
Pharmaceutical Law (PHL)
English / SE
1.00
1.00

Course description

Knowledge of the relevant legal provisions concerning medicinal products and medical devices law in Europe and Austria; the target is to create a general understanding for legal issues on the basis of a well-defined part of the law. Practical use of the course is the principal aim.

Methodology

Lecture and discussions in interactive workshops

Learning outcomes

After passing this course successfully students are able to ...

  • name the legal basics of pharmaceutical law and medical devices law,
  • register simple legal problems in theses areas and develop general solutions for simple situations ,
  • catch general problems of more complicated legal issues tob e in the position to prepare measures to solve these problems,
  • distinguish between pharmaceuticals and medical devices,
  • check clinical trial contracts concerning the most relevant issues,
  • explain the principles of marketings authorisation procedures,
  • describe the nature of a patent.

Course contents

  • Principles of pharmaceutical law and medical devices law in Europe and Austria
  • Distinguishing between pharmaceutical products and medical devices including discussion of recent jurisdiction
  • Development of pharmaceutical products and medical devices mainly focussed on clinical trials and related legal questions
  • Introduction to patent law including procedural topics
  • Proceedings and applications for marketing authorisations of pharmaceutical products

Prerequisites

Definitions of terms: - Law- Directive- Regulation- NotificationInstitutions and government in Europe (Knowledge of general responsibilities and tasks): - European Parliament- Commission- European Court of JusticeInstitutions and government in Austria (Knowledge of general responsibilities and tasks):- Parliament- Government- Differences between EU-law and national law- Legislative bodies in the EU and Austria- Public authorities in Austria- Definition of a contract according to civil law

Literature

  • Lecture mainly refers to the published legal basic on the so-called Eudralex homepage, especially the Community Code relating to medical products for human use. Further necessary documents are distributed in class.refer http://ec.europa.eu/health/documents/eudralex/index_en.htm

Assessment methods

  • written exam (50 points)
From DNA to Protein 1 (kM13)
English / kMod
7.00
-
Bioinformatics (BIO)
English / SE
1.00
1.00

Course description

Bioinformatics methods and tools for sequence analysis, protein structure prediction as well as for the analysis of high-throughput Omics datasets (genomics, transcriptomics, proteomics, metabolomics) will be introduced. Commonly used biological databases from NCBI, UniProt and Ensembl will be discussed. Methods and tools will be applied in practical courses on real-word biomedical datasets.

Methodology

Discussed bioinformatics methods will be applied in two practice courses on real word biomedical datasets.

Learning outcomes

After passing this course successfully students are able to ...

  • give an overview of bioinformatics fields of application and associated theoretical background
  • solve selected bioinformatics tasks independently

Course contents

  • Overview of bioinformatics areas and the theoretical background as well as used methods
  • Biological databases
  • Background of high-throughput Omics experiments
  • Analysis of high-throughput Omics datasets
  • Bioinformatics analysis of with selected examples during practice courses

Prerequisites

- Basics in computer handling - Basics in statistics - Basics in biology, medicine

Literature

  • .

Assessment methods

  • Writte exam at the end
  • Evaluation of practice course protocols
  • Exam and protocols account for 50% of the final degree each and both have to be positively completed

Anmerkungen

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Molecular Biochemistry and Cell Biology (MBC)
English / ILV
6.00
2.50

Course description

The students obtain detailed knowledge of fundamental molecular and cellular processes in eukaryotic cells and understand their relevance for tissue engineering and regenerative medicine.

Methodology

- Lectures- Distance learning (eLearning)

Learning outcomes

After passing this course successfully students are able to ...

  • give a detailed overview of the essential genetic mechanisms of the cell (replication, transcription, translation, regulation of gene expression, repair, and recombination)
  • specify cellular components (membranes, cytoskeleton, intracellular compartments), protein sorting, and intracellular membrane traffic, and explicate basic mechanisms underlying cell communication, cell cycle, and cell division
  • update this knowledge and integrate it into the concepts of tissue engineering and regenerative medicine with relevant publications
  • solve straightforward, research-based thought problems, related to the above mentioned contents

Course contents

  • DNA structure and functionality
  • regulation of gene expression
  • internal organisation of the cell

Prerequisites

basic knowledge of biochemistry and molecular biology

Literature

  • Alberts, Bruce et al., (2014): Molecular Biology of the Cell, Garland Science

Assessment methods

  • successfully complete the eLearning elements
  • active participation
  • final written exam
Laboratory Work in Teams 1 (iM11)
English / iMod
7.00
-
Project Laboratory 1 (PL1)
English / PRJ
6.00
3.00

Course description

Groups of approximately three students work independently on different practical methods and their theoretical backgrounds relevant for Tissue Engineering and Regenerative Medicine.

Methodology

Every group of students is supervised by a lecturer, who guides them throughout the semester. In the lab students are supervised by the members of the Competence Team "Tissue Engineering Bioreactors".

Learning outcomes

After passing this course successfully students are able to ...

  • perform basic steps in cell culture (cell seeding and counting, growth curve, cell stainings) and 2 (out of 4) techniques relevant in tissue engineering (preparation of silk scaffolds, RT-PCR, Western blotting, primary cell culture)
  • identify relevant literature, write a scientific introduction and develop and implement a working plan on a given topic
  • evaluate and interpret their scientific results, summarize them in a written report (IMRAD-structure) and present them to supervisors, lecturers and students
  • keep records on their laboratory experiments
  • approach and solve scientific problems within a team

Course contents

  • Scientific literature research and writing of a scientific introduction
  • Planning experiments
  • Writing a scientific report
  • Conducting experiments in the lab
  • Presentation of the obtained data in front of an auditorium (consisting of the other groups and all supervising lecturers)

Prerequisites

Basic knowledge about cell and tissue biology as well as corresponding lab experience.

Literature

  • current scientific literature

Assessment methods

  • Exams
  • Documentation of lab work (lab book)<
  • Presentation of data
  • Writing reports
  • Performance in the lab
  • Documentation of the whole project
Team Management (TEA)
English / SE
1.00
0.50

Course description

In the course the students get to know main principles of leading teams.

Learning outcomes

After passing this course successfully students are able to ...

  • explain the role of leadership in the different stages of team development (for example by Tuckman) and to derive relevant leading actions (for example directive leadership in the forming phase).
  • diagnose dynamics in project teams using models (for example Rank Dynamics, Drama Triangle, TZI) and to develop and argue case-related concrete opportunities for activities (for example delegation of responsibilty, critical discussion).

Course contents

  • Leadership functions and tasks
  • Leadership tools in project teams
  • Role conflicts "colleague" and "project leader"
  • Leading without formal power and competence
  • Overview of theories to group dynamics
  • Conflicts and difficult situations in leading project teams

Literature

  • Berkun, S. (2005): The Art of Project Management, Sebastopol: O’Reilly Media
  • Cronenbroeck, W. (2008): Projektmanagement, Berlin: Cornelsen Verlag [bilingual book: in English and German]
  • Haeske, U. (2008): Teamentwicklung, Berlin: Cornelsen Verlag, [bilingual book: in English and German]

Assessment methods

  • An individual reflection paper about the group processes encountered in the semester and how the knowledge about group dynamic processes and communication models was applied.

Anmerkungen

The course also includes team coaching for the teams in the course Project Laboratory 1.

Protein Chemistry (iM15)
English / iMod
4.00
-
Protein Chemistry (PRO)
English / ILV
4.00
3.00

Course description

The students obtain knowledge about structure, function as well as analytics of proteins. Additionally, selected therapeutics based on proteins are discussed.

Methodology

- PowerPoint presentations- Workshops- Seminar talks

Learning outcomes

After passing this course successfully students are able to ...

  • explain the composition and chemical structure of proteins and name modifications and their functions
  • name the most important methods for the chemical analysis of proteins and explain their basic principles
  • explain the basic mechanisms of protein function
  • explain interactions between proteins using examples

Course contents

  • Chemical structure of proteins
  • Post-translational modifications
  • Bioinformatics
  • Protein quantification
  • Separation techniques
  • Proteomics
  • Protein function
  • Enzymes, antibodies, structural proteins
  • Protein therapeutics

Prerequisites

- Basics of organic and analytical chemistry- Basics of cell biology

Literature

  • Behme, Stefan (2015): Manufacturing of Pharmaceutical Proteins, Wiley-Blackwell
  • Lottspeich, Friedrich / Engels, Joachim W (2013): Bioanalytik, Spektrum Akademischer Verlag
  • Petsko, Gregory A / Ringe, Dagmar (2008): Protein Structure and Function, Oxford University Press
  • Stryer, Lubert (2015): Biochemistry, W. H. Freeman

Assessment methods

  • Active participation
  • Seminar talk
  • Written exam
Tissue Engineering (kM14)
English / kMod
8.00
-
Biomaterials in Tissue Engineering (BMT)
English / ILV
2.00
1.00

Course description

The students obtain knowledge medical applications of biomaterials as well as about basic concepts regarding design and mechanical properties of selected natural and synthetic biomaterials. Topics from current research projects of the UAS Tech are explained and discussed.

Methodology

- Lecture/Presentation- Discussion

Learning outcomes

After passing this course successfully students are able to ...

  • describe the basic techniques to manufacture scaffolds from raw biomaterials and explain the different prerequisites for the biomaterials.
  • explain nature design concepts in the biomaterials field.
  • differentiate biomaterials regarding their properties and assess their usage in a specific application.
  • describe the most common techniques to test cell biocompatibility of biomaterials and apply them on different biomaterials.
  • correlate the protein structure of a biomaterial with its properties as a biomaterial.

Course contents

  • Elements of biomaterials
  • Self-assembly and growth
  • Mechanical concepts in biomaterials
  • Different protein fibers: collagen, silk, keratin
  • Methods for the determination of biocompatibility
  • Soft tissue - skin
  • Cartilage
  • Biological composite materials e.g. fibers
  • Hierarchical design bone, wound care und suture materials, vascular implants, biomimetic and bio-inspired materials

Prerequisites

Basics of chemistry and protein chemistry

Literature

  • Gordana Vunjak-Novakovic, R. Ian Freshney (2006): Culture of Cells for Tissue Engineering, Wiley
  • Ulrich Meyer, Thomas Meyer, Jörg Handschel, Hans Peter Wiesmann (2009): Fundamentals of Tissue Engineering and Regenerative Medicine, Springer
  • Relevant publications will be provided via CIS

Assessment methods

  • Final exam
Tissue Engineering for Regenerative Medicine (TER)
English / ILV
6.00
2.00

Course description

In the first part of the course the most important tools used in tissue engineering (e.g. cells, scaffolds, cell-cell communication,…) are discussed. After an intermediate exam, the second part of the course at the one hand deals with tissue engineering concepts and strategies of different tissue types (e.g. cartilage, bone,…), on the other hand with the application of cells in regenerative medicine. Course contents are deepened by activities of the students during the course.

Methodology

- Lectures- Distance learning- Team work and presentations of the students- Guest lectures

Learning outcomes

After passing this course successfully students are able to ...

  • name different cell types, explain their characteristics and select them for different applications in tissue engineering
  • list different methods for scaffold production and explain their advantages and disadvantages for application in tissue engineering
  • describe different methods for cell differentiation and select suitable detection methods for cell differentiation
  • describe the correlation between different tissue components (cells, extracellular matrix,…) and define differences between selected tissue types
  • describe and compare different tissue engineering concepts using examples
  • give an overview about the application of cells for regenerative medicine, name examples and explain advantages and disadvantages of stem cells as therapeutics

Course contents

  • Components used in tissue engineering
  • Primary cells, cell lines and immortalization of cells
  • Extracellular matrix
  • Communication between cells
  • First steps of animal development
  • Cell differentiation and stem cells
  • Scaffolds for tissue engineering
  • Tissue engineering of bones and cartilage
  • Skin tissue engineering and application
  • Heart valves tissue engineering
  • Cell therapy in regenerative medicine
  • Immunomodulation of mesenchymal stem cell
  • Biofabrication

Prerequisites

- basic knowledge in cell biology- basic knowledge in biochemistry

Literature

  • Gordana Vunjak-Novakovic, R. Ian Freshney (2006): Culture of Cells for Tissue Engineering, Wiley
  • Ulrich Meyer, Thomas Meyer, Jörg Handschel, Hans Peter Wiesmann (2009): Fundamentals of Tissue Engineering and Regenerative Medicine, Springer
  • Relevant literature (e.g. papers) will be provided

Assessment methods

  • Collaboration during lessons
  • Distance learning
  • Presentations
  • Intermediate written exam
  • Final written exam

2. Semester

Name ECTS
SWS
Bioreactors and Biotechnology (kM23)
English / kMod
7.00
-
Bioreactors in Tissue Engineering (BRTE)
English / ILV
4.00
2.00

Course description

The students obtain knowledge about bioreactors in Tissue Engineering and Regenerative Medicine applications. Furthermore basic concepts regarding design and triggered cellular and tissue effects will be discussed.

Methodology

VO - Basics and TheorieSE - Discussion of Examples and Modells for BioreactorsSE - Discussion of Design Concepts and outcomes

Learning outcomes

After passing this course successfully students are able to ...

  • define the term „Bioreactorsystems in Tissue Engineering” and differentiate them from bioreactors in biotechnology
  • define the common bioreactor types and explain their working principle.
  • explain the main idea of the “in vivo bioreactor” concept with examples from the course.
  • define the two main rationales to use bioreactors in tissue engineering.
  • evaluate advantages and disadvantages of different bioreactor systems in regard to their application for a specific tissue type.
  • develop a basic bioreactor system for a certain organ/tissue and simulate elementary processes inside the bioreactor.
  • explain common types of sensors for bioreactor systems and apply these sensors on a specific bioreactor application.

Course contents

  • Mechanics of Bioreactors
  • Electronical Control Design of Bioreactors
  • Connecting Points to Bioreactors used in Biotechnology
  • Feedback Control Basics
  • Literature Discussion of Common Bioreactor Types (including critical discussion)
  • Discussion of Commerically Available Biorecator Systems
  • Interdisciplinary Approach on the Design of Bioreactors for Tissue Engineering
  • Key Parameters involved in Bioreactor Design
  • Scaffolds and Constructs for Bioreactor Systems (including adapted Fabrication Techniques)
  • Control and Feedback Control in Mechatronics for Mechanical Stimulation
  • Basics of Mechanotransduction - Signalling Pathways
  • Biosensors and Actors for Bioreactors
  • Biochemical Basics for Nutrition and Growth of living Cells
  • "Functional Tissue Engineering”
  • "in-vivo” Bioreactors - idea and current approaches
  • "Lessons learned from research projects of the FHTW"

Prerequisites

- Cell biology - Basic knowledge on Mechanics, Electronics, Biomaterials and Cell cuture

Literature

  • Gordana Vunjak-Novakovic, R. Ian Freshney (2006): Culture of Cells for Tissue Engineering, Wiley
  • Ulrich Meyer, Thomas Meyer, Jörg Handschel, Hans Peter Wiesmann (2009): Fundamentals of Tissue Engineering and Regenerative Medicine, Springer
  • C. Kasper, M. Van Griensven, R. Pörtner (2008): Bioreactor Systems for Tissue Engineering, Springer
  • Relevant publications will be provided via CIS

Assessment methods

  • Course immanent assessment method and end exam
Biotechnology (BT)
English / ILV
3.00
2.00

Course description

Design and optimisation of recombinant protein production

Methodology

Basics and theory are presented in interaktive lectures.Selected topics are elaborated and presented by students.Case studies are presented in Seminars andExcursions.

Learning outcomes

After passing this course successfully students are able to ...

  • design a bioprocess for recombinant protein production using microbial and/or mammalian cell systems starting from gene to the purified product.
  • design and describe the operation of different types of bioreactors
  • select the appropriate expression host and vector system
  • define strategies for host and product development
  • explain the concept and principles of bioprocess design (up- and
  • downstream processing)
  • apply high level data exploration and interpretation using examples
  • combine the acquired knowledge with state of the art scientific progress
  • describe, interpret, apply and present the function and interactivity of complex systems

Course contents

  • Upstream processing:
  • production organisms - overview
  • cultivation equipment (bioreactor, monitoring)
  • process operation
  • case study - process design

Prerequisites

Basics in biology, mathematics, physics

Literature

  • Bioprocess Engineering Principles, Pauline M Doran, Academic Press ISBN-12-220855-2 ISBN 0-12-220856-0 pbk
  • Horst Chmiel, Bioprozesstechnik, ISBN: 3827416078

Assessment methods

  • written exams
  • immanent assessment of presentations
From DNA to Protein 2 (kM22)
English / kMod
9.00
-
Gene Regulation and Signal Transduction (GRST)
English / VO
3.00
2.00

Course description

This course provides necessary information to understand cellular signalling and how genes are regulated. The topics cover aspects of signal transduction in the context of tissue engineering and regenerative medicine.

Methodology

Lecture presenting basics and applied examples.

Learning outcomes

After passing this course successfully students are able to ...

  • explain the basic principles of DNA/protein interaction
  • specify components and regulation of important signaling pathways (e.g. Raf-MEK-ERK, PI3K-AKT-mTOR; apoptosis) and mechanisms of mechanotransduction
  • interpret and analyze results from typical signaling experiments (Western blots, IPs…)
  • explicate the relevance of signal transduction in Tissue Engineering

Course contents

  • signaling pathways (RAF-MEK-ERK, mTOR/AKT, Wnt/beta-catenin)
  • apoptosis
  • mechanotransduction
  • aspects of cellular signaling in Tissue Engineering

Prerequisites

Molecular Biochemistry and Cell Biology

Literature

  • current scientific literature suggested by lecturers

Assessment methods

  • final written exam
Methods in Cellbiology (incl. Lab) (MIC)
English / ILV
6.00
2.00

Course description

This course provides information to learn about cellbiological methods. The content will partly be explained in lectures and partly by performing exercises in the laboratory.

Methodology

- Lectures- Discussions and lab experiments

Learning outcomes

After passing this course successfully students are able to ...

  • describe different methods to measure the binding of proteins to DNA.
  • explain different sequencing methods.
  • explain approaches and methods for the generation of conventional and conditional knock out mice and genotype tissue samples with provided sequences and primers
  • perform cell migration/transwell-assays and interpret them independently
  • design gene-specific primers for RT-qPCR, investigate the gene-expression via RT-qPCR and distinguish this method from other gene-expression analysis techniques.
  • describe the system, functional principle and experimental limitations of a confocal microscope
  • sketch the morphologic structure of mitochondria as well as the mitochondrial respiratory transport chain, prepare mitochondria from tissue, measure mitochondrial respiratory activity including ATP levels and determine the protein content in mitochondrial suspensions.
  • describe the operating mode of a Scanning Electron Microscope (SEM) including preparation techniques and perform basic sample preparations individually as well as investigate them with SEM.

Course contents

  • SEM sample preparation and individual analysis with SEM

Prerequisites

- Project Laboratory 1- Molecular Biochemistry and Cell Biology- Tissue Engineering and Regenerative Medicine- Protein Chemistry

Literature

  • Goldstein, Joseph / Newbury, Dale / Joy David (2007): Scanning Electron Micrsoscopy and X-Ray Microanalysis, Springer
  • Echlin Patrick (2009): Handbook of Sample Preparation for Scanning Electron Micrsoscopy and X-Rey Microanalysis

Assessment methods

  • Basis for grading are collaboration, homework, written protocols and a final exam.
Laboratory Work in Teams 2 (iM21)
English / iMod
7.00
-
Project Laboratory 2 (PRL2)
English / PRJ
6.00
3.00

Course description

Teams of 3-4 students work on a scientific project in the field of tissue engineering and regenerative medicine independently.

Methodology

Self-dependent working on research concepts, doing experiments in the lab, interpretation of resultsAll groups are supervised by a lecturer who guides them thoughout the semester

Learning outcomes

After passing this course successfully students are able to ...

  • develop individual ideas regarding a specific problem in tissue engineering and regenerative medicine based on scientific literature and under supervision of a senior researcher as well as planning of the corresponding experiments.
  • apply different methods of tissue engineering and regenerative medicine in a teams (using existing work protocols)
  • elaborate a working plan according to a predefined project plan and define single working packages
  • present and interpret the obtained results in a scientifically correct manner
  • create a scientific poster according to certain requirements and present the data to supervisors and colleagues.
  • writing a scientific report following the IMRAD structure
  • effectively assign and complete defined tasks in a team

Course contents

  • individual planning of experiments based on scientific literature research under supervision of researchers
  • experimental work in the lab
  • interpretation and discussion of the obtained results
  • Presentation of the obtained data in an poster session at the end of the semester
  • writing a scientific report following the IMRAD structure

Prerequisites

Passed course PL1 of the first semester.

Literature

  • current scientific literature

Assessment methods

  • practical work in the lab
  • database
  • lab book
  • poster presentation
  • introduction
  • intermediate reports
  • final report
  • oral exam
Project Management and Leadership (PML)
English / SE
1.00
0.50

Course description

This course provides an overview of the latest practice and current theories of leadership. One of the course’s fundamental components will be the student’s reflection of their behaviour about particular issues concerning leadership in project management.

Learning outcomes

After passing this course successfully students are able to ...

  • identify and to explain tasks and instruments of leadership (for example delegation, agreement on objectives).
  • explain classical management models (for example leading continuum, Maturity Model) and to apply to practical examples.
  • describe different assumptions about human nature (for example McGregor) and to derive the consequences for the leading of co-workers.

Course contents

  • Leadership styles and instruments (for example staff appraisal)
  • Motivation, promotion and development of employees
  • Leadership functions versus professional tasks
  • Consequence of “not leading”
  • Role of the leader in a change process
  • Dealing with crises, success and failures

Prerequisites

Team Management Skills

Literature

  • Daft, R. (2008): New Era of Management, Mason/Ohio:Thomson
  • Pettinger, R. (2007): Introduction to Management, Houndmills/Hampshire: Palgrave Macmillan
  • Schermerhorn, J. (2008): Management, Hoboken/New Jersey: John Wiley

Assessment methods

  • Reflection paper (grade)

Anmerkungen

The course also includes team coaching for the teams in the course Project Laboratory 1.

Scientific Research Design, Evaluation and Communication (kM24)
English / kMod
7.00
-
Ethics in Engineering and Medicine (EEM)
English / SE
1.00
1.00

Course description

The course imparts basic knowledge of bioethics to the students. Ethical questions in bioengineering and biomedicine including their impacts on society and the training of ethical decision-making and argumentation take center stage.

Methodology

Seminar: - Theory Inputs- Case Studies- Group work- Ethical arguing- Discussions

Learning outcomes

After passing this course successfully students are able to ...

  • outline selected basic terms and principles of biomedical ethics (for example moral status, allocation ethics, concepts of health and disease/disabilities) by the means of simple examples.
  • apply ethical standards to latest research developments in selected actual case studies in bioengineering and biotechnology.
  • describe the steps of ethical decision-making and argumentation and to apply them in selected case studies for ethical assessment of conflicting issues in the field of biomedical research and medicine.

Course contents

  • Fundamental positions of bioethical decision-making and argumentation
  • Experiments with human subjects and animals
  • Ethics issues of resource allocation
  • Ethical concepts to health-disease/illness-disabilities
  • Intercultural ethical aspects of bioengineering and biotechnology
  • Selection of actual subjects of biotechnology and / bioethics

Literature

  • Literature at the beginning of the course

Assessment methods

  • Course with an immanent character (grade):
Projectmanagement for (Bio)Pharmaceutical Products (PPP)
English / SE
2.00
2.00

Course description

Lecture covers the major aspects of Project Management in general and in particular for Product Development as applied in the Biopharmaceutical Industry.

Methodology

exercises, case studies, discussion, theory inputs, self-learning phases supported by e-learning

Learning outcomes

After passing this course successfully students are able to ...

  • - explain project management methods and to develop project plans (PMA) as well as to apply and follow up these in their own laboratory projects
  • - explain the project phases of (bio) pharmaceutical development projects and their main results
  • - explain the main challenges of pharmaceutical development
  • - analyze the company structure as part of the project environment, to explain their advantages and disadvantages and to recognize and analyze important influencing factors and deviations, and to develop a constructive approach to these factors (with appropriate assistance)
  • - explain the interdependence of the project boundaries
  • - explain the team structure with its roles and responsibilities

Course contents

  • - application of project management tools and techniques (PMA)
  • Project management for product development in biopharmaceutical Industry
  • - Key Issues in pharmaceutical industry and its impact on drug development
  • - Product life cycle of biologics / drug project phases / product pipeline
  • - Challenges in pharmaceutical development projects with case studies and exercises

Prerequisites

fundamentals of project management

Literature

  • Gareis, Roland (2005), Happy Projects!, MANZ, Vienna; ISBN3-214-08268-X
  • Patzak, Gerold & Rattay, Günter, Project Management, Linde, Vienna; ISBN978-3-7143-0224-0

Assessment methods

  • Course immanent assessment method

Anmerkungen

All grading components have to be completed positively.

Study Design and Biostatistics (SDB)
English / VO
3.00
2.00

Course description

The first part of the course provides an overview including details of different study design concepts. Subsequently, some selected parts of biostatistics are discussed. Additionally students present scientific literature in an oral presentation and receive detailed feedback on their presentation skills.

Methodology

- Lecture format- Occasional take-home readings- Discussions in classroom

Learning outcomes

After passing this course successfully students are able to ...

  • define general rules/key points of an appropriate study design
  • identify types of models/study design approaches utilized in various areas of pre- and clinical research
  • define and critically assess the influence of key advantages and weaknesses of most commonly modeling systems used in pre- and clinical research
  • define basic rules/definitions used in biomedical descriptive statistics
  • perform a critical preliminary assessment of (quantitative) data as well as selection of appropriate tests for statistical evaluation of (quantitative) data
  • define most common do’s and don’t’s in a power point presentation
  • define/practically apply the optimal tactics for an effective scientific meeting-type talk
  • apply a “damage control” in the post-talk question/answer period

Course contents

  • Study design overview for 1) in vitro, 2) in vivo and 3) clinical study sections
  • Detailed description of study types, their applicability and pro-and cons for each section.
  • Selected (introductory) study design-related aspects of biostatistics: types of data, distributions/normality, hypothesis testing, data transformation, appropriate approach/selection of statistical tests
  • Curriculum also includes graded data presentation training (a.k.a. Power Talk Training) by students in a form of a 10min power point (PP) talk/each (followed by a detailed feedback from the lecturer)

Prerequisites

- An open mind and mental flexibility- Positive thinking and eagerness to interact with the lecturer- Knowledge of the basic statistical concepts is useful

Assessment methods

  • Final grade will combine 50% of the test score and 50% of the PP talk.

Anmerkungen

Students must get approval of the topics to present from the lecturer; titles/topics need to be sent to the lecturer at least 3 days before the scheduled talk. The order of individual talks is to be decided by students.

Writing Scientific English (WSE)
English / SE
1.00
1.00

Course description

We aim at conveying the language-related and formal criteria required for scientific abstracts

Methodology

Lecture and discussion. Extensive teacher and peer feedback of written work (three writing assignments involving the writing of abstracts)

Learning outcomes

After passing this course successfully students are able to ...

  • structure scientific abstracts according to the formal criteria given
  • write scientific abstracts according to the language-related criteria given

Course contents

  • The role, content, style and types (i.e. research and review) of scientific abstracts
  • Structure of a scientific abstract
  • Language-related criteria of a scientific abstract
  • Writing a scientific abstract

Prerequisites

Passed course Advanced English of the first semester.

Literature

  • Göschka, M. et al (2014) Guidelines for Scientific Writing, Skriptum
  • Additional current handouts

Assessment methods

  • The students’ grade will depend upon:
  • His/Her attendance and participation in class discussions
  • The quality of written assignments
  • Personal improvement of his/her English and communication skills

3. Semester

Name ECTS
SWS
Economic & Legal Issues and Professional Communication 2 (kM34)
English / kMod
7.00
-
Case Studies in Pharmaceutical Industries (CSPI)
English / SE
2.00
2.00

Course description

The course provides insights into the daily practice of management in pharmaceutical companies to the students. Subjects are based on the four management tasks Planning, Organizing, Leading and Controlling, as covered in the course Corporate Management (COM/MTE1). Also Pharma Marketing subjects as discussed in the course Economics & Marketing (EMA/MTE3) will be studied in practical cases.

Methodology

- Solutions of case studies in group work as well presenting and discussing these with all members of the class- Roleplays of practical situations of pharma management- Partly short theoretical introductions with lectures and powerpoint charts- Case master solutions will be provided

Learning outcomes

After passing this course successfully students are able to ...

  • analyze and evaluate financial information of a pharmaceutical company (Financial Statements, Planning etc.)
  • develop suitable measures of crisis management in a pharmaceutical company (Action Plan, Communication, Savings Programs etc.)
  • conduct analyses to prepare a decision about a merger of two pharma companies
  • hold difficult meetings with direct reports in daily operations of a pharmaceutical business
  • recognize the importance of company politics in a global pharmaceutical enterprise and develop according ways to behave in this environment
  • develop options for a good cross-functional cooperation in a global pharmaceutical company
  • evaluate advantages and disadvantages of various forms of communication in a company
  • develop suitable ways to motivate employees in a company, particularly top talents

Course contents

  • Case study solution methodology, crisis management, project management, financial analysis, communication, business evaluation, talent management, investment analysis, motivation of employees, asset management, financing resources, entrepreneurship, audits, pharmaceutical sales call, change management, compliance, negotiations and meetings.

Prerequisites

Course Corporate Management (COM/MTE1)

Literature

  • Stephen P. Robbins, David A. DeCenzo, Mary CoulterFundamentals of ManagementPearson Education, 2014, 9th Global EditionISBN-10: 1292056541ISBN-13: 978-1292056548

Assessment methods

  • Paper with case study – weight 50%
  • Active Class Input (Groups, Plenum) – weight 50%. Students must achieve at least 50% in both assessment elements
Economics and Marketing (EM)
English / VO
3.00
2.00

Course description

The objective of this class is to provide an understanding how healthcare markets work, particularly the Pharma market, and how market participants behave there. Students will learn how pharmaceutical companies can use marketing tools to successfully conduct analyses, develop strategies and market products. The limits set for Health Care Marketing by Compliance will also be discussed in the course. Finally students will get familiar with methods of Pharmacoeconomy which are being used to evaluate the economic benefit of health care products – an aspect that is getting more and more important in an industry trying to limit growing costs.

Methodology

Lectures with Powerpoint charts, discussions and case studies in methods of Pharmacooeconomy. .

Learning outcomes

After passing this course successfully students are able to ...

  • explain the economic behavior of supply and demand on markets
  • describe and evaluate the various types of markets, particularly also in the context of health care products and different health care systems
  • explain and evaluate various marketing strategies, particularly in connection with the product life cycle
  • evaluate the instruments of the “Marketing Mix” (4 P’s) to achieve specific marketing goals
  • conduct a health care sales call
  • recognize, evaluate and explain the limits of healthcare marketing as set by compliance rules
  • calculate the pharmacoeconomic utility of a treatment or a product applying various methods
  • prepare, justify and evaluate a marketing plan for a health care product including quantified goals (Income Statement)

Course contents

  • Healthcare markets (Global and Austria, particularly also the Austrian reimbursement system), essential elements of microeconomic theory (Demand and supply, market types based on competition etc.), healthcare marketing (Mix of marketing tools, strategies, marketing plan, sales call and marketing compliance, distribution, pricing, promotion etc.), methods of pharmacoeconomy using case studies.

Literature

  • Walter J. Wessels – Economics, Barrons 2012, 5th Edition, ISBN 13: 978-0764147609
  • Dimitris Dogramatzis - Pharmaceutical Marketing, A Practical Guide, Informa Healthcare 2007, 4th Edition, ISBN 10: 1-57491-118-X (Hardcover), ISBN 13: 978-1-57491-118-3 (Hardcover)
  • Karen L. Rascati - Pharmacooeconomics , Lippincott Williams & Wilkins 2013, ISBN-10: 1451175930, ISBN-13: 978-1451175936

Assessment methods

  • Written Exam (2 h) at the end of the course – weight 60%Marketing Plan Paper – weight 40%. Students must achieve at least 50% in both assessment elements.
Management for Quality in Biomedicine (MQB)
English / ILV
2.00
1.00

Course description

In the first part of the course, students are given an introduction to quality management systems (QMS) acc. to ISO 9001 and 13485.The second part centers on topics relevant for pharmaceutical industry: GMP, qualification and validation.

Learning outcomes

After passing this course successfully students are able to ...

  • draft SOPs
  • check the structure of a QMS
  • set up a validation concept for an analytical method, a process or an equipment and to present it
  • to apply FMEA for risk assessment independently

Course contents

  • Principles of Quality Management Systems acc. to ISO 9001 and 13485GMP, GDP, GLP; qualification of equipment; validation of methods and processes

Literature

  • MHRA: Rules and Guidance for Pharmaceutical Manufacturers and Distributors; 2014

Assessment methods

  • Course immanent assessment method and end exam
Methods of Scientific Research (iM35)
English / iMod
8.00
-
Methods of Scientific Research (MSR)
English / PRJ
8.00
0.00

Course description

This course is intended as initial training for the master's thesis

Methodology

Practical work in the laboratory

Learning outcomes

After passing this course successfully students are able to ...

  • define a scientific working plan under supervision of a researcher
  • apply methods in tissue engineering on a certain scientific problem
  • select scientific literature for a special scientific question, extract relevant information and discuss them with a supervisor

Course contents

  • Literature research concerning topics of the master´s thesis.
  • Formal and organizational procedure regarding the master´s thesis
  • planning and conception of the master´s thesis
  • first practical experiments under supervision of supervisors.

Prerequisites

Practical experience in the laboratory, gained in the first two semesters of this study program

Assessment methods

  • short seminar paper in the field of the master´s thesis.
Nanotechnologies (iM32)
English / iMod
4.00
-
Nanotechnologies (NT)
English / ILV
4.00
2.00

Course description

Overview of the nanobiotechnological application potential as well as deepening of several sub-topics.

Methodology

- Lectures- Presentations- Self-dependent working on exercises- Videos

Learning outcomes

After passing this course successfully students are able to ...

  • define the concept of thermal energy and relate such concept to understand life-time interactions in biological systems.
  • describe the principle of electron microscopy (EM) and atomic force microscopy (AFM) for the elucidation of the nanostructure of biomaterials as well as to measure molecular forces between molecules (AFM).
  • explain molecular modifications for synthetic biointerfaces that control interactions with molecules in biological fluids
  • describe and evaluate the colloidal aspects of current nanoscale drug delivery systems.
  • explain the term biosensor and describe the physical background of optical biosensors (focus on plasmonic properties) including their application in bioassays
  • explain different microfabrication methods and microfluidic components, describe the physical principles regarding fluids on a microscale and give application examples for cell analysis based on lab-on-chips
  • explain the biochemical principles behind binding events relevant for microarrays and give specific examples in which fields microarrays are used.
  • describe the biochemical principles of molecular nanomotors based on proteins and nucleic acids and give examples of the application potential of such structures

Course contents

  • Biosensors
  • Functional biointerfaces
  • Biomembranes
  • Characterization of nanostructures
  • Drug delivery
  • Lithography and miniaturization
  • Microfluidics
  • Lab-on-a-chip application
  • Molecular recognition and interaction
  • Microarrays
  • Molecular nanomotors

Prerequisites

Biochemistry, basics in physics

Literature

  • Nanobiotechnology II, Wiley-VCH by Mirkin et al.
  • Biomedical Nanostructures, Wiley by Consalves et al.
  • Wissenschaftliche Literatur aus der LV
  • Matthew A. Cooper, Label-Free Biosensors, Cambridge University Press, 2009.
  • F. S. Ligler (editor), Optical Biosensors: Present and Future, Elsevier, 2002
  • B. E. A. Saleh, M. C. Teich, Fundamentals of Photonics, John Wiley & Sons, 1991.

Assessment methods

  • Collaboration during the lectures
  • Presentations
  • Self-dependent solution of exercises
  • Final exam
Regenerative Medicine (kM33)
English / kMod
5.00
-
Current Problems in Regenerative Medicine (CPRM)
English / SE
1.00
1.00

Course description

This course is intended to give an overview of the current topics in regenerative medicine. For this purpose different talks and/or workshops are part of this course. Additionally, a problem-based learning part is included where the students work on a topic individually.

Methodology

Lectures, paper presentations

Learning outcomes

After passing this course successfully students are able to ...

  • describe the areas of application in the field of regenerative medicine
  • give examples and descriptions of current research projects in the field of regenerative medicine
  • give a detailed description of a certain topic of regenerative medicine

Course contents

  • ...
  • describe the areas of application in the field of regenerative medicine
  • give examples and descriptions of current research projects in the field of regenerative medicine
  • give a detailed description of a certain topic of regenerative medicine

Prerequisites

Reading and understanding of scientific research papers and fundamental knowledge in biochemistry and cell biology

Assessment methods

  • Presentation of scientific papers
Stem Cells in Regenerative Medicine (SCRM)
English / ILV
4.00
2.00

Course description

In the first part of the course selected chapters of stem cell biology and the application potential of stem cells (course contains self-study units) are discussed. After accomplishing an exam in the second part of the course students as well as experts in the field of stem cell research present current data.

Learning outcomes

After passing this course successfully students are able to ...

  • name the different types of stem cells including their properties and functions.
  • explain the factors guiding the different processes in stem cells.
  • define possible applications of stem cells in the field of tissue engineering.
  • prepare given papers about stem cells and present them to their colleagues.

Course contents

  • different types of stem cells (ESC, adult SC, iPS, fetal SC)
  • definition and characteristics of stem cells
  • stem cell niche and its relevance in the development of diseases
  • fate decision of stem cells
  • application potential of stem cells
  • ethics and legal issues of stem cells

Prerequisites

- Molecular Biochemistry and Cell Biology of the first semester- Gene Regulation and Signal of the second semester

Literature

  • Robert Lanza and Anthony Atala (2014): Essentials of Stem Cell Biology, (third edition), Elsevier., ISBN: 978-0-12-409503-8

Assessment methods

  • intermediate and end exam
Tissue Engineering 2 (kM31)
English / kMod
6.00
-
Advanced Immunology and Vascular Tissue Engineering (AIVTE)
English / ILV
4.00
2.00

Course description

This lecture helps to extend and deepen the knowledge of immunological processes in connection to tissue engineering. Furthermore, basic knowledge in vascular biology will be taught. This is necessary to understand the principles of vascular tissue engineering

Methodology

- Lecture- Presentations- Group puzzle

Learning outcomes

After passing this course successfully students are able to ...

  • apply complex immunological processes to tissue engineering
  • describe the cascades of the wound healing process
  • describe the processes of formation of blood and lymphatic vessels
  • recapitulate the principles of vascular tissue engineering

Course contents

  • Wound healing
  • Inflammation
  • Complement system
  • Transplantation
  • Graft rejection
  • Angiogenesis
  • Lymphangiogenesis
  • Endothelial cells in research
  • Examples of Vascular tissue engineering

Prerequisites

Basic knowledge of immunology

Literature

  • Current literature (papers) provided during the lecture

Assessment methods

  • Group puzzle
  • Collaboration
  • Paper presentation
  • Examination (the grades of the exam is the basis, up- or down grading is possible by the other assessment criteria)
Biochemical Research Papers (BR)
English / ILV
1.00
1.00

Course description

In this course the contents and structure of scientific publications and grants will be analyzed according to different criteria and publishing of a paper will be demonstrated. Furthermore, students present and discuss selected scientific papers.

Methodology

Lectures, e-learing, discussions, presentations

Learning outcomes

After passing this course successfully students are able to ...

  • analyse and present scientific papers
  • specify quality criteria of scientific work and include them in own papers (ie: Master thesis)
  • cite correctly
  • write scientific texts

Course contents

  • Structure of scientific publications
  • critical assessment of scientifc publications („good“ versus „bad“ papers) according to defined criteria
  • review process
  • presentations of scientific publications according to selected examples

Prerequisites

knowledge in literature research writing a scientific thesis (including an abstract)

Literature

  • slides, moodle-tool and recent papers

Assessment methods

  • Course immanent assessment method (e-learning tasks (40%) und presentations (60%))

Anmerkungen

The e-learning courses can be passed at the FH Technikum or at home. The tool is only provided in a certain time of the course. Advantage at the FH: lecturer is present for questions.

Project Laboratory 3 (PL3)
English / PRJ
1.00
0.50

Course description

Based on the results of their semester projects in the second semester (Project Laboratory 2), students write a fictuous grant proposal for a follow-up project in compliance with formal and content guidelines of a funding agency, drawing on their prior knowledge and experience in project management. Subsequently, students take on the role of a reviewer in a peer-review process and critically reflect on the projects. Students consequently present and defend their improved project proposals in front of an expert jury.

Learning outcomes

After passing this course successfully students are able to ...

  • write a grant proposal in compliance to formal guidelines and content criteria of a funding partner/agency.
  • formulate written feedback to a project proposal in a peer-review process as well as critically discuss and reflect on both, positive aspects and weak points of a proposal.
  • present and defend a project proposal in a hearing in front of an expert jury.

Course contents

  • Grant application – formal procedure, guidelines, content
  • Peer-review process, Criteria for assessing project proposals, difference of peer-review process in grant application and academic publications
  • Preparation hearing, criteria hearing
  • Method: Development and practice of all course content on the basis of students‘ own projects (online-course with home assignments; feedback, reflection and presentations in presence-units)

Prerequisites

Module Laboratory Work in Teams 1 + 2, Project Management in (Bio)Pharmaceutical Industries, Writing Scientific English

Assessment methods

  • Course immanent assessment method

Anmerkungen

Blended-learning format with limited presence-units, alignment of relevant content with the course “Biochemical Research Papers”

4. Semester

Name ECTS
SWS
Master's Thesis (iM41)
English / iMod
30.00
-
Master's Thesis (MT)
English / BE
28.00
0.00

Course description

Students perform scientific research work under supervision of a senior researcher and write a master´s thesis following the IMRAD structure.

Learning outcomes

After passing this course successfully students are able to ...

  • work on a scientific question and perform experiments autonomously.
  • evaluate and analyze scientific data and present them adequately in their thesis.
  • write a thesis, considering commonly accepted criteria (IMRAD-structure, correct citation, figures) in English.

Course contents

  • Practical work on a scientific question under supervision and writing of the master´s thesis according to the guidelines of the UAS.

Prerequisites

All technical courses of the curriculum

Literature

  • Scientific literature in the field of the master´s theses.

Assessment methods

  • Course immanent assessment method and end exam.
Seminar for Degree Candidates (SDC)
English / SE
2.00
0.25

Course description

This course aims at exchange of results and experiences during the master´s thesis.

Learning outcomes

After passing this course successfully students are able to ...

  • summarize scientific results adequately and present them to colleagues and lecturers
  • assess their work (and that from colleagues) critically and propose solutions
  • explain and stand up for the results and conclusions obtained during the master´s thesis in a discussion

Course contents

  • Students present updates of their master´s projects to the whole class and the lecturers of the course (FH-supervisors of the master´s theses)

Prerequisites

Project Laboratory 1 and Project Laboratory 2

Assessment methods

  • Course immanent assessment method (presentation, active participation)