Tissue Engineering and Regenerative Medicine: Curriculum

Here you'll find detailed information on current courses of the Master's degree program Tissue Engineering and Regenerative Medicine. Please note that due to ongoing updates not all courses of the program might be fully displayed. A complete overview of the curriculum for the study year 2016/17 is going to be published in the course of the summer semester 2016.

1. Semester

Name ECTS
SWS
Economic and Legal Issues and Professional Communication 1 (kM12)
English / kMod
4.00
-
Corporate Management (COM)
English / SE
2.00
2.00

Course description

The course shall provide an overview over the essential elements of Management in order to prepare the students for managerial tasks in practical business life. After an introduction to basics of management (managers, environment, social responsibility) the course covers the 4 managerial steps Planning, Organizing, Leading and Control. Practical examples focus particularly on the pharmaceutical industry.

Methodology

Lectures with Powerpoint Slides as well as discussions and several case studies.

Learning outcomes

After passing this course successfully students are able to ...

  • define tasks and steps of the managerial process for companies as well as explain examples for “effective” and “efficient” management
  • analyze the economic situation of a company as a manager, for example by using comparative data in income statements
  • develop and define company goals as a manager
  • make decisions as a manager as well as to explain and justify them
  • recognize critical situations in terms of business ethics and develop solutions
  • explain methods how to motivate employees and evaluate their applicability in practical cases
  • evaluate various methods of communication for practical management
  • explain leadership styles and their advantages and disadvantages for specific situations and persons

Course contents

  • Basics of management, decision making in business, planning, organizational structure and culture, change management, time management, managing teams, motivation of employees, leadership traits and styles, communication in business, controlling, key factors of successful management

Literature

  • Stephen P. Robbins, David A. DeCenzo, Mary CoulterFundamentals of ManagementPearson Education, 2014, 9th Global EditionISBN-10: 1292056541ISBN-13: 978-1292056548

Assessment methods

  • End exam
Pharmaceutical Law (PHL)
English / SE
1.00
1.00

Course description

Knowledge of the relevant legal provisions concerning medicinal products and medical devices law in Europe and Austria; the target is to create a general understanding for legal issues on the basis of a well-defined part of the law. Practical use of the course is the principal aim.

Methodology

Lecture and discussions in interactive workshops

Learning outcomes

After passing this course successfully students are able to ...

  • name the legal basics of pharmaceutical law and medical devices law,
  • register simple legal problems in theses areas and develop general solutions for simple situations ,
  • catch general problems of more complicated legal issues tob e in the position to prepare measures to solve these problems,
  • distinguish between pharmaceuticals and medical devices,
  • check clinical trial contracts concerning the most relevant issues,
  • explain the principles of marketings authorisation procedures,
  • describe the nature of a patent.

Course contents

  • Principles of pharmaceutical law and medical devices law in Europe and Austria
  • Distinguishing between pharmaceutical products and medical devices including discussion of recent jurisdiction
  • Development of pharmaceutical products and medical devices mainly focussed on clinical trials and related legal questions
  • Introduction to patent law including procedural topics
  • Proceedings and applications for marketing authorisations of pharmaceutical products

Prerequisites

Definitions of terms: - Law- Directive- Regulation- NotificationInstitutions and government in Europe (Knowledge of general responsibilities and tasks): - European Parliament- Commission- European Court of JusticeInstitutions and government in Austria (Knowledge of general responsibilities and tasks):- Parliament- Government- Differences between EU-law and national law- Legislative bodies in the EU and Austria- Public authorities in Austria- Definition of a contract according to civil law

Literature

  • Lecture mainly refers to the published legal basic on the so-called Eudralex homepage, especially the Community Code relating to medical products for human use. Further necessary documents are distributed in class.refer http://ec.europa.eu/health/documents/eudralex/index_en.htm

Assessment methods

  • written exam (50 points)
Reporting and Data Presentation (RDP)
English / SE
1.00
1.00
From DNA to Protein 1 (iM13)
English / kMod
6.00
-
Molecular Biochemistry and Cell Biology (MBC)
English / ILV
6.00
2.00

Course description

The students obtain detailed knowledge of fundamental molecular and cellular processes in eukaryotic cells and understand their relevance for tissue engineering and regenerative medicine.

Methodology

- Lectures - Distance learning (eLearning) - groupwork

Learning outcomes

After passing this course successfully students are able to ...

  • give a detailed overview of the essential genetic mechanisms of the cell (replication, transcription, translation, regulation of gene expression, repair, and recombination)
  • specify cellular components (membranes, cytoskeleton, intracellular compartments), protein sorting, and intracellular membrane traffic, and explicate basic mechanisms underlying cell communication, cell cycle, and cell division
  • update this knowledge and integrate it into the concepts of tissue engineering and regenerative medicine with relevant publications
  • solve straightforward, research-based thought problems, related to the above mentioned contents

Course contents

  • DNA structure and functionality
  • regulation of gene expression
  • internal organisation of the cell

Prerequisites

basic knowledge of biochemistry and molecular biology

Literature

  • Alberts, Bruce et al., (2014): Molecular Biology of the Cell, Garland Science

Assessment methods

  • successfully complete the eLearning elements
  • active participation
  • final written exam
Laboratory Work in Teams 1 (iM11)
English / iMod
8.00
-
Project Laboratory 1 (PL1)
English / PRJ
8.00
3.00

Course description

Teams of approximately three students each learn methods relevant to tissue engineering and regenerative medicine in theory and practice. The work is carried out independently. Furthermore, students get familiar with the main principles of leading teams.

Methodology

Self-directed learning, supported by short inputs in seminars, exercises and teaching materials (compulsory literature and current research papers), as well as continuous feedback on written and practical work. Each student team is supervised by a lecturer who guides them throughout the semester. During practical laboratory work, students are supported by research supervisors (R & D staff). In accompanying team coaching sessions students reflect on aspects of group-dynamics.

Learning outcomes

After passing this course successfully students are able to ...

  • independently perform basic steps in cell culture (cell seeding and counting, growth curve, cell stainings. primary cell culture) and techniques relevant in tissue engineering of molecular biology (e.g. RT-PCR, Western blotting) and biomaterials (e.g. preparation of silk-scaffolds and Hydrogels).
  • explain the theoretical background, mechanisms, advantages and disadvantages and application scenarios of these methods and to identify typical application errors.
  • identify relevant literature, write a scientific introduction and develop and implement a working plan on a given topic.
  • comprehensibly analyze, critically evaluate and interpret their data collected with the help of scientific-systematic methods, to summarize them in a written report according to the standard of scientific working (IMRAD structure) and to present their results to supervisors, lecturers and fellow students.
  • record their laboratory experiments in a laboratory book in a comprehensible manner in accordance with prescribed standards of scientific documentation.
  • approach and solve scientific problems within a team.
  • identify the basic types of scientific publications and differentiate between them, especially original papers, review papers, conference articles, journals and books.
  • evaluate subject specific literature sources (also in English) regarding confirmability, dependability, plausibility, and transferability of insights for comparable problems or contexts and use and reference these in their own work.
  • plan the phases of a scientic study, conduct it precisely, document it comprehensibly, and to ensure the comprehensibility, dependability, plausibility and transferability other problems areas and contexts.
  • relate research results to industry, society, the economy or the environment.
  • explain the role of leadership in the different stages of team development (for example by Tuckman) and to derive relevant leading actions (for example directive leadership in the forming phase).
  • diagnose dynamics in project teams using models (for example Rank Dynamics, Drama Triangle, TZI) and to develop and argue case-related concrete opportunities for activities (for example delegation of responsibilty, critical discussion).

Course contents

  • Scientific literature research and writing of a scientific introduction
  • Planning experiments
  • Statistical tests and preparation of results
  • Writing a scientific report
  • Conducting experiments in the lab
  • Leadership functions and tasks, Leadership tools in project teams, Role conflicts "colleague" and "project leader", Leading without formal power and competence, Overview of theories to group dynamics, Conflicts and difficult situations in leading project teams
  • Presentation of the obtained data in front of an auditorium (consisting of the other teams and all supervising lecturers)

Prerequisites

Basic knowledge about cell and tissue biology and molecular biology as well as corresponding lab experience, warm-up course cell culture and lab security training.

Literature

  • Berkun, S. (2005): The Art of Project Management, Sebastopol: O’Reilly Media
  • Cronenbroeck, W. (2008): Projektmanagement, Berlin: Cornelsen Verlag [bilingual book: in English and German]
  • Haeske, U. (2008): Teamentwicklung, Berlin: Cornelsen Verlag, [bilingual book: in English and German]
  • Current scientific literature (research papers)
  • Script cell culture

Assessment methods

  • Exams
  • Documentation of lab work (lab book)
  • Presentation of data
  • Writing reports
  • Performance in the lab with examinations
  • Documentation of the whole project
  • An individual reflection paper about the group processes encountered in the semester and how the knowledge about group dynamic processes and communication models was applied.

Anmerkungen

This course also includes team coaching for the teams in the course Project Laboratory 1.

Protein Chemistry (iM15)
English / iMod
3.00
-
Protein Chemistry (PRO)
English / ILV
3.00
2.00
Tissue Engineering 1 (kM14)
English / kMod
9.00
-
Biomaterials in Tissue Engineering (BMT)
English / ILV
3.00
2.00
Tissue Engineering for Regenerative Medicine (TER)
English / ILV
6.00
2.00

2. Semester

Name ECTS
SWS
Bioreactors and Biotechnology (kM23)
English / kMod
7.00
-
Bioreactors and Biophysical Therapies (BRTE)
English / ILV
4.00
2.00
Biotechnology (BT)
English / ILV
3.00
2.00
From DNA to Protein 2 (kM22)
English / kMod
9.00
-
Gene Regulation and Signal Transduction (GRST)
English / VO
3.00
2.00

Course description

This course provides necessary information to understand cellular signalling and how genes are regulated. The topics cover aspects of signal transduction in the context of tissue engineering and regenerative medicine.

Methodology

Lecture presenting basics and applied examples.

Learning outcomes

After passing this course successfully students are able to ...

  • explain the basic principles of DNA/protein interaction
  • specify components and regulation of important signaling pathways (e.g. Raf-MEK-ERK, PI3K-AKT-mTOR; apoptosis) and mechanisms of mechanotransduction
  • interpret and analyze results from typical signaling experiments (Western blots, IPs…)
  • explicate the relevance of signal transduction in Tissue Engineering

Course contents

  • signaling pathways (RAF-MEK-ERK, mTOR/AKT, Wnt/beta-catenin)
  • apoptosis
  • mechanotransduction
  • aspects of cellular signaling in Tissue Engineering

Prerequisites

Molecular Biochemistry and Cell Biology

Literature

  • current scientific literature suggested by lecturers

Assessment methods

  • final written exam
Methods in Cellbiology (incl. Lab) (MIC)
English / ILV
6.00
2.00

Course description

This course provides information to learn about cellbiological methods. The content will partly be explained in lectures and partly by performing exercises in the laboratory.

Methodology

- Lectures- Discussions and lab experiments

Learning outcomes

After passing this course successfully students are able to ...

  • describe different methods to measure the binding of proteins to DNA.
  • explain different sequencing methods.
  • explain approaches and methods for the generation of conventional and conditional knock out mice and genotype tissue samples with provided sequences and primers
  • perform cell migration/transwell-assays and interpret them independently
  • design gene-specific primers for RT-qPCR, investigate the gene-expression via RT-qPCR and distinguish this method from other gene-expression analysis techniques.
  • describe the system, functional principle and experimental limitations of a confocal microscope
  • sketch the morphologic structure of mitochondria as well as the mitochondrial respiratory transport chain, prepare mitochondria from tissue, measure mitochondrial respiratory activity including ATP levels and determine the protein content in mitochondrial suspensions.
  • describe the operating mode of a Scanning Electron Microscope (SEM) including preparation techniques and perform basic sample preparations individually as well as investigate them with SEM.

Course contents

  • SEM sample preparation and individual analysis with SEM

Prerequisites

- Project Laboratory 1- Molecular Biochemistry and Cell Biology- Tissue Engineering and Regenerative Medicine- Protein Chemistry

Literature

  • Goldstein, Joseph / Newbury, Dale / Joy David (2007): Scanning Electron Micrsoscopy and X-Ray Microanalysis, Springer
  • Echlin Patrick (2009): Handbook of Sample Preparation for Scanning Electron Micrsoscopy and X-Rey Microanalysis

Assessment methods

  • Basis for grading are collaboration, homework, written protocols and a final exam.
Laboratory Work in Teams 2 (iM21)
English / iMod
7.00
-
Project Laboratory 2 (PRL2)
English / PRJ
7.00
2.00

Course description

Teams of 3-4 students work on a scientific project in the field of tissue engineering and regenerative medicine independently.

Methodology

Self-dependent working on research concepts, doing experiments in the lab, interpretation of results. All groups are supervised by a lecturer and a scientist who guide them thoughout the semester

Learning outcomes

After passing this course successfully students are able to ...

  • develop individual ideas regarding a specific problem in tissue engineering and regenerative medicine based on scientific literature and under supervision of a senior researcher as well as planning of the corresponding experiments.
  • apply different methods of tissue engineering and regenerative medicine in a teams (using existing work protocols)
  • elaborate a working plan according to a predefined project plan and define single working packages
  • present and interpret the obtained results in a scientifically correct manner
  • create a scientific poster according to certain requirements and present the data to supervisors and colleagues.
  • writing a scientific report following the IMRAD structure
  • effectively assign and complete defined tasks in a team
  • evaluate subject specific literature sources (also in English) regarding confirmability, dependability, plausibility, and transferability of insights for comparable problems or contexts and use and reference these in their own work
  • justify a research question after identifying the current state of the art with regard to scientific considerations, formulate the question comprehensibly and to define verifiable target criteria
  • plan the phases of a scientic study, conduct it precisely, document it comprehensibly, and to ensure the comprehensibility, dependability, plausibility and transferability other problems areas and contexts
  • relate research results to industry, society, the economy or the environment.
  • present own or other scientific publications comprehensibly, evaluate them and formulate suggestions for further development.

Course contents

  • individual planning of experiments based on scientific literature research under supervision of researchers
  • experimental work in the lab
  • interpretation and discussion of the obtained results
  • Presentation of the obtained data in a poster session at the end of the semester
  • writing a scientific report following the IMRAD structure

Prerequisites

Passed course PL1 of the first semester.

Literature

  • current scientific literature

Assessment methods

  • practical work in the lab
  • lab book
  • poster presentation
  • written asignments (introduction, intermediate reports, final report)
  • oral exam
Scientific Research Design, Evaluation and Communication (kM24)
English / kMod
7.00
-
Ethics in Engineering and Medicine (EEM)
English / SE
1.00
1.00

Course description

The course imparts basic knowledge of bioethics to the students. Ethical questions in bioengineering and biomedicine including their impacts on society and the training of ethical decision-making and argumentation take center stage.

Methodology

Seminar: - Theory Inputs- Case Studies- Group work- Ethical arguing- Discussions

Learning outcomes

After passing this course successfully students are able to ...

  • outline selected basic terms and principles of biomedical ethics (for example moral status, allocation ethics, concepts of health and disease/disabilities) by the means of simple examples.
  • apply ethical standards to latest research developments in selected actual case studies in bioengineering and biotechnology.
  • describe the steps of ethical decision-making and argumentation and to apply them in selected case studies for ethical assessment of conflicting issues in the field of biomedical research and medicine.

Course contents

  • Fundamental positions of bioethical decision-making and argumentation
  • Experiments with human subjects and animals
  • Ethics issues of resource allocation
  • Ethical concepts to health-disease/illness-disabilities
  • Intercultural ethical aspects of bioengineering and biotechnology
  • Selection of actual subjects of biotechnology and / bioethics

Literature

  • Literature at the beginning of the course

Assessment methods

  • Course with an immanent character (grade):
Projectmanagement for (Bio)Pharmaceutical Products (PPP)
English / SE
2.00
2.00

Course description

Lecture covers the major aspects of Project Management in general and in particular for Product Development as applied in the Biopharmaceutical Industry.

Methodology

exercises, case studies, discussion, theory inputs, self-learning phases supported by e-learning

Learning outcomes

After passing this course successfully students are able to ...

  • - explain project management methods and to develop project plans (PMA) as well as to apply and follow up these in their own laboratory projects
  • - explain the project phases of (bio) pharmaceutical development projects and their main results
  • - explain the main challenges of pharmaceutical development
  • - analyze the company structure as part of the project environment, to explain their advantages and disadvantages and to recognize and analyze important influencing factors and deviations, and to develop a constructive approach to these factors (with appropriate assistance)
  • - explain the interdependence of the project boundaries
  • - explain the team structure with its roles and responsibilities

Course contents

  • - application of project management tools and techniques (PMA)
  • Project management for product development in biopharmaceutical Industry
  • - Key Issues in pharmaceutical industry and its impact on drug development
  • - Product life cycle of biologics / drug project phases / product pipeline
  • - Challenges in pharmaceutical development projects with case studies and exercises

Prerequisites

fundamentals of project management

Literature

  • Gareis, Roland (2005), Happy Projects!, MANZ, Vienna; ISBN3-214-08268-X
  • Patzak, Gerold & Rattay, Günter, Project Management, Linde, Vienna; ISBN978-3-7143-0224-0

Assessment methods

  • Course immanent assessment method

Anmerkungen

All grading components have to be completed positively.

Study Design and Biostatistics (SDB)
English / VO
3.00
2.00

Course description

The first part of the course provides an overview including details of different study design concepts. Subsequently, some selected parts of biostatistics are discussed. Additionally students present scientific literature in an oral presentation and receive detailed feedback on their presentation skills.

Methodology

- Lecture format- Occasional take-home readings- Discussions in classroom

Learning outcomes

After passing this course successfully students are able to ...

  • define general rules/key points of an appropriate study design
  • identify types of models/study design approaches utilized in various areas of pre- and clinical research
  • define and critically assess the influence of key advantages and weaknesses of most commonly modeling systems used in pre- and clinical research
  • define basic rules/definitions used in biomedical descriptive statistics
  • perform a critical preliminary assessment of (quantitative) data as well as selection of appropriate tests for statistical evaluation of (quantitative) data
  • define most common do’s and don’t’s in a power point presentation
  • define/practically apply the optimal tactics for an effective scientific meeting-type talk
  • apply a “damage control” in the post-talk question/answer period

Course contents

  • Study design overview for 1) in vitro, 2) in vivo and 3) clinical study sections
  • Detailed description of study types, their applicability and pro-and cons for each section.
  • Selected (introductory) study design-related aspects of biostatistics: types of data, distributions/normality, hypothesis testing, data transformation, appropriate approach/selection of statistical tests
  • Curriculum also includes graded data presentation training (a.k.a. Power Talk Training) by students in a form of a 10min power point (PP) talk/each (followed by a detailed feedback from the lecturer)

Prerequisites

- An open mind and mental flexibility- Positive thinking and eagerness to interact with the lecturer- Knowledge of the basic statistical concepts is useful

Assessment methods

  • Final grade will combine 50% of the test score and 50% of the PP talk.

Anmerkungen

Students must get approval of the topics to present from the lecturer; titles/topics need to be sent to the lecturer at least 3 days before the scheduled talk. The order of individual talks is to be decided by students.

Writing Scientific English (WSE)
English / SE
1.00
1.00

3. Semester

Name ECTS
SWS
Advanced Technologies in Biological Research (iM32)
English / iMod
4.00
-
Advanced Technologies in Biological Research (ATBR)
English / ILV
4.00
2.00
Economic & Legal Issues and Professional Communication 2 (kM34)
English / kMod
7.00
-
Case Studies in Pharmaceutical Industries (CSPI)
English / SE
2.00
2.00

Course description

The course provides insights into the daily practice of management in pharmaceutical companies to the students. Subjects are based on the four management tasks Planning, Organizing, Leading and Controlling, as covered in the course Corporate Management (COM/MTE1). Also Pharma Marketing subjects as discussed in the course Economics & Marketing (EMA/MTE3) will be studied in practical cases.

Methodology

- Solutions of case studies in group work as well presenting and discussing these with all members of the class- Roleplays of practical situations of pharma management- Partly short theoretical introductions with lectures and powerpoint charts- Case master solutions will be provided

Learning outcomes

After passing this course successfully students are able to ...

  • analyze and evaluate financial information of a pharmaceutical company (Financial Statements, Planning etc.)
  • develop suitable measures of crisis management in a pharmaceutical company (Action Plan, Communication, Savings Programs etc.)
  • conduct analyses to prepare a decision about a merger of two pharma companies
  • hold difficult meetings with direct reports in daily operations of a pharmaceutical business
  • recognize the importance of company politics in a global pharmaceutical enterprise and develop according ways to behave in this environment
  • develop options for a good cross-functional cooperation in a global pharmaceutical company
  • evaluate advantages and disadvantages of various forms of communication in a company
  • develop suitable ways to motivate employees in a company, particularly top talents

Course contents

  • Case study solution methodology, crisis management, project management, financial analysis, communication, business evaluation, talent management, investment analysis, motivation of employees, asset management, financing resources, entrepreneurship, audits, pharmaceutical sales call, change management, compliance, negotiations and meetings.

Prerequisites

Course Corporate Management (COM/MTE1)

Literature

  • Stephen P. Robbins, David A. DeCenzo, Mary CoulterFundamentals of ManagementPearson Education, 2014, 9th Global EditionISBN-10: 1292056541ISBN-13: 978-1292056548

Assessment methods

  • Paper with case study – weight 50%
  • Active Class Input (Groups, Plenum) – weight 50%. Students must achieve at least 50% in both assessment elements
Economics and Marketing (EM)
English / VO
3.00
2.00

Course description

The objective of this class is to provide an understanding how healthcare markets work, particularly the Pharma market, and how market participants behave there. Students will learn how pharmaceutical companies can use marketing tools to successfully conduct analyses, develop strategies and market products. The limits set for Health Care Marketing by Compliance will also be discussed in the course. Finally students will get familiar with methods of Pharmacoeconomy which are being used to evaluate the economic benefit of health care products – an aspect that is getting more and more important in an industry trying to limit growing costs.

Methodology

Lectures with Powerpoint charts, discussions and case studies regardingmethods of Pharmacooeconomy. .

Learning outcomes

After passing this course successfully students are able to ...

  • explain the economic behavior of supply and demand on markets
  • describe and evaluate the various types of markets, particularly also in the context of health care products and different health care systems
  • explain and evaluate various marketing strategies, particularly in connection with the product life cycle
  • evaluate the instruments of the “Marketing Mix” (4 P’s) to achieve specific marketing goals
  • conduct a health care sales call
  • recognize, evaluate and explain the limits of healthcare marketing as set by compliance rules
  • calculate the pharmacoeconomic utility of a treatment or a product applying various methods
  • prepare, justify and evaluate a marketing plan for a health care product including quantified goals (Income Statement)

Course contents

  • Healthcare markets (Global and Austria, particularly also the Austrian reimbursement system), essential elements of microeconomic theory (Demand and supply, market types based on competition etc.), healthcare marketing (Mix of marketing tools, strategies, marketing plan, sales call and marketing compliance, distribution, pricing, promotion etc.), methods of pharmacoeconomy using case studies.

Literature

  • Walter J. Wessels – Economics, Barrons 2012, 5th Edition, ISBN 13: 978-0764147609
  • Dimitris Dogramatzis - Pharmaceutical Marketing, A Practical Guide, Informa Healthcare 2007, 4th Edition, ISBN 10: 1-57491-118-X (Hardcover), ISBN 13: 978-1-57491-118-3 (Hardcover)
  • Karen L. Rascati - Pharmacooeconomics , Lippincott Williams & Wilkins 2013, ISBN-10: 1451175930, ISBN-13: 978-1451175936

Assessment methods

  • Written Exam (2 h) at the end of the course – weight 40%. Marketing Plan Paper – weight 60%. Students must achieve at least 50% in both assessment elements.
Management for Quality in Biomedicine (MQB)
English / ILV
2.00
2.00

Course description

The course is structured in 3 parts: 1st lecture provides students an introduction to quality management systems (QMS) based on ISO 9001 and links the content to specific GxP requirements within fields of Biotechnology. The 2nd lecture focuses on the introduction and applying of quality and risk management tools. The 3rd lecture deals with specifics of the regulated industry, i.e. Qualification / Validation. Examples are derived from the daily business working within the regulated industry.

Learning outcomes

After passing this course successfully students are able to ...

  • create SOPs.
  • identify the elements and structure of a QMS and now the major regulations.
  • apply quality and risk management tools.
  • setup a concept to validate /qualify an analytical method / process or equipment.
  • understand the challenges of quality within regulated industry

Course contents

  • Basics of Quality Management Systems acc. ISO 9001, GxP, qualification of equipment, validation of methods and processes

Literature

  • ISO: ISO9001:2015
  • FDA: 21 CFR Part 58, 210/211, 820, 1270/1271 (www.fda.gov)
  • ICH Q-series (www.ich.org)
  • EudraLex EU legislation (https://ec.europa.eu/health/documents/eudralex_en)
  • Advanced therapies (EC) No 1394/2007
  • In-vitro Diagnostic Directive (IVDD) 98/79/EC
  • Medical Device Directive (MDD) Directive 93/42/EEC
  • WHO – Quality Guidelines (http://www.who.int/medicines/areas/quality_safety/quality_assurance/guidelines/en/)

Assessment methods

  • Course immanent assessment method and end exam
Methods of Scientific Research (iM35)
English / iMod
8.00
-
Methods of Scientific Research (MSR)
English / PRJ
8.00
0.00

Course description

This course is intended as initial training for the master's thesis

Methodology

Practical work in the laboratory

Learning outcomes

After passing this course successfully students are able to ...

  • define a scientific working plan under supervision of a researcher
  • apply methods in tissue engineering on a certain scientific problem
  • select scientific literature for a special scientific question, extract relevant information and discuss them with a supervisor
  • identify the basic types of scientific publications and differentiate between them, especially original papers, review papers, conference articles, journals and books
  • evaluate subject specific literature sources (also in English) regarding confirmability, dependability, plausibility, and transferability of insights for comparable problems or contexts and use and reference these in their own work
  • justify a research question after identifying the current state of the art with regard to scientific considerations, formulate the question comprehensibly and to define verifiable target criteria
  • plan the phases of a scientic study, conduct it precisely, document it comprehensibly, and to ensure the comprehensibility, dependability, plausibility and transferability other problems areas and contexts
  • chose and apply relevant methods for the research question and compose the structure, a proposal and the Master thesis, especially experimental research methods
  • relate research results to industry, society, the economy or the environment.
  • present own or other scientific publications comprehensibly, evaluate them and formulate suggestions for further development.

Course contents

  • Literature research concerning topics of the master´s thesis.
  • Formal and organizational procedure regarding the master´s thesis
  • planning and conception of the master´s thesis
  • first practical experiments under supervision of supervisors.

Prerequisites

Practical experience in the laboratory, gained in the first two semesters of this study program

Assessment methods

  • short seminar paper in the field of the master´s thesis.
Regenerative Medicine (kM33)
English / kMod
6.00
-
Current Problems in Regenerative Medicine (CPRM)
English / SE
2.00
2.00
Stem Cells in Regenerative Medicine (SCRM)
English / ILV
4.00
2.00

Course description

In the first part of the course selected chapters of stem cell biology and the application potential of stem cells (course contains self-study units) are discussed. After accomplishing an exam in the second part of the course students as well as experts in the field of stem cell research present current data.

Learning outcomes

After passing this course successfully students are able to ...

  • name the different types of stem cells including their properties and functions.
  • explain the factors guiding the different processes in stem cells.
  • define possible applications of stem cells in the field of tissue engineering.
  • prepare given papers about stem cells and present them to their colleagues.

Course contents

  • different types of stem cells (ESC, adult SC, iPS, fetal SC)
  • definition and characteristics of stem cells
  • stem cell niche and its relevance in the development of diseases
  • fate decision of stem cells
  • application potential of stem cells
  • ethics and legal issues of stem cells

Prerequisites

- Molecular Biochemistry and Cell Biology of the first semester- Gene Regulation and Signal of the second semester

Literature

  • Robert Lanza and Anthony Atala (2014): Essentials of Stem Cell Biology, (third edition), Elsevier., ISBN: 978-0-12-409503-8

Assessment methods

  • intermediate and end exam
Tissue Engineering 2 (kM31)
English / kMod
5.00
-
Advanced Immunology and Vascular Tissue Engineering (AIVTE)
English / ILV
4.00
2.00

Course description

This lecture helps to extend and deepen the knowledge of immunological processes in connection to tissue engineering. Furthermore, basic knowledge in vascular biology will be taught. This is necessary to understand the principles of vascular tissue engineering

Methodology

- Lecture- Presentations- Group puzzle

Learning outcomes

After passing this course successfully students are able to ...

  • apply complex immunological processes to tissue engineering
  • describe the cascades of the wound healing process
  • describe the processes of formation of blood and lymphatic vessels
  • recapitulate the principles of vascular tissue engineering

Course contents

  • Wound healing
  • Inflammation
  • Complement system
  • Transplantation
  • Graft rejection
  • Angiogenesis
  • Lymphangiogenesis
  • Endothelial cells in research
  • Examples of Vascular tissue engineering

Prerequisites

Basic knowledge of immunology

Literature

  • Current literature (papers) provided during the lecture

Assessment methods

  • Group puzzle
  • Collaboration
  • Paper presentation
  • Examination (the grades of the exam is the basis, up- or down grading is possible by the other assessment criteria)
Project Laboratory 3 (PL3)
English / PRJ
1.00
1.00

4. Semester

Name ECTS
SWS
Master's Thesis (iM41)
English / iMod
30.00
-
Master's Thesis (MT)
English / BE
28.00
0.00

Course description

Students perform scientific research work under supervision of a senior researcher and write a master´s thesis following the IMRAD structure.

Learning outcomes

After passing this course successfully students are able to ...

  • work on a scientific question and perform experiments autonomously.
  • evaluate and analyze scientific data and present them adequately in their thesis.
  • write a thesis, considering commonly accepted criteria (IMRAD-structure, correct citation, figures) in English.

Course contents

  • Practical work on a scientific question under supervision and writing of the master´s thesis according to the guidelines of the UAS.

Prerequisites

All technical courses of the curriculum

Literature

  • Scientific literature in the field of the master´s theses.

Assessment methods

  • Course immanent assessment method and end exam.
Seminar for Degree Candidates (SDC)
English / SE
2.00
0.25

Course description

This course aims at exchange of results and experiences during the master´s thesis.

Learning outcomes

After passing this course successfully students are able to ...

  • summarize scientific results adequately and present them to colleagues and lecturers
  • assess their work (and that from colleagues) critically and propose solutions
  • explain and stand up for the results and conclusions obtained during the master´s thesis in a discussion

Course contents

  • Students present updates of their master´s projects to the whole class and the lecturers of the course (FH-supervisors of the master´s theses)

Prerequisites

Project Laboratory 1 and Project Laboratory 2

Assessment methods

  • Course immanent assessment method (presentation, active participation)