Tissue Engineering and Regenerative Medicine: Curriculum

Here you'll find detailed information on current courses of the Master's degree program Tissue Engineering and Regenerative Medicine. Please note that due to ongoing updates not all courses of the program might be fully displayed. A complete overview of the curriculum for the study year 2016/17 is going to be published in the course of the summer semester 2016.

1. Semester

Name ECTS
SWS
Economic and Legal Issues and Professional Communication 1 (kM12)
English / kMod
4.00
-
Advanced English (ADE)
English / SE
1.00
1.00

Course description

We aim at conveying the language-related criteria and techniques required for leading and participating in discussions and writing a summary on current issues and topics in the Cell and Tissue Engineering profession

Methodology

Seminar

Learning outcomes

After passing this course successfully students are able to ...

  • lead a professional discussion in English, i.e. to apply appropriate language and techniques for effective research, formulation of questions, moderation, summarizing etc.;
  • write a summary of the facts and main arguments of relevant topics

Course contents

  • Language and techniques for leading a professional discussion
  • Defining, researching, presenting, and leading a discussion on an appropriate professional topic
  • Vocabulary work-up based on research sources for the discussion topic
  • Writing a summary of the main facts and arguments pertaining to the discussion topic

Prerequisites

Common European Framework of Reference for Languages Level B2

Literature

  • Göschka, M. et al. (2014) Guidelines for Scientific Writing, Skriptum
  • Harvard Business Review 20-Minute Manager Series: Running Meetings
  • Additional current handouts

Assessment methods

  • active participation in class activities and timely completion of assignments
Corporate Management (COM)
English / SE
2.00
2.00

Course description

The course shall provide an overview over the essential elements of Management in order to prepare the students for managerial tasks in practical business life. After an introduction to basics of management (managers, environment, social responsibility) the course covers the 4 managerial steps Planning, Organizing, Leading and Control. Practical examples focus particularly on the pharmaceutical industry.

Methodology

Lectures with Powerpoint Slides as well as discussions and several case studies.

Learning outcomes

After passing this course successfully students are able to ...

  • define tasks and steps of the managerial process for companies as well as explain examples for “effective” and “efficient” management
  • analyze the economic situation of a company as a manager, for example by using comparative data in income statements
  • develop and define company goals as a manager
  • make decisions as a manager as well as to explain and justify them
  • recognize critical situations in terms of business ethics and develop solutions
  • explain methods how to motivate employees and evaluate their applicability in practical cases
  • evaluate various methods of communication for practical management
  • explain leadership styles and their advantages and disadvantages for specific situations and persons

Course contents

  • Basics of management, decision making in business, planning, organizational structure and culture, change management, time management, managing teams, motivation of employees, leadership traits and styles, communication in business, controlling, key factors of successful management

Literature

  • Stephen P. Robbins, David A. DeCenzo, Mary CoulterFundamentals of ManagementPearson Education, 2014, 9th Global EditionISBN-10: 1292056541ISBN-13: 978-1292056548

Assessment methods

  • End exam
Pharmaceutical Law (PHL)
English / SE
1.00
1.00

Course description

Knowledge of the relevant legal provisions concerning medicinal products and medical devices law in Europe and Austria; the target is to create a general understanding for legal issues on the basis of a well-defined part of the law. Practical use of the course is the principal aim.

Methodology

Lecture and discussions in interactive workshops

Learning outcomes

After passing this course successfully students are able to ...

  • name the legal basics of pharmaceutical law and medical devices law,
  • register simple legal problems in theses areas and develop general solutions for simple situations ,
  • catch general problems of more complicated legal issues tob e in the position to prepare measures to solve these problems,
  • distinguish between pharmaceuticals and medical devices,
  • check clinical trial contracts concerning the most relevant issues,
  • explain the principles of marketings authorisation procedures,
  • describe the nature of a patent.

Course contents

  • Principles of pharmaceutical law and medical devices law in Europe and Austria
  • Distinguishing between pharmaceutical products and medical devices including discussion of recent jurisdiction
  • Development of pharmaceutical products and medical devices mainly focussed on clinical trials and related legal questions
  • Introduction to patent law including procedural topics
  • Proceedings and applications for marketing authorisations of pharmaceutical products

Prerequisites

Definitions of terms: - Law- Directive- Regulation- NotificationInstitutions and government in Europe (Knowledge of general responsibilities and tasks): - European Parliament- Commission- European Court of JusticeInstitutions and government in Austria (Knowledge of general responsibilities and tasks):- Parliament- Government- Differences between EU-law and national law- Legislative bodies in the EU and Austria- Public authorities in Austria- Definition of a contract according to civil law

Literature

  • Lecture mainly refers to the published legal basic on the so-called Eudralex homepage, especially the Community Code relating to medical products for human use. Further necessary documents are distributed in class.refer http://ec.europa.eu/health/documents/eudralex/index_en.htm

Assessment methods

  • written exam (50 points)
From DNA to Protein 1 (kM13)
English / kMod
7.00
-
Bioinformatics (BIO)
English / SE
1.00
1.00

Course description

Bioinformatics methods and tools for sequence analysis, protein structure prediction as well as for the analysis of high-throughput Omics datasets (genomics, transcriptomics, proteomics, metabolomics) will be introduced. Commonly used biological databases from NCBI, UniProt and Ensembl will be discussed. Methods and tools will be applied in practical courses on real-word biomedical datasets.

Methodology

Discussed bioinformatics methods will be applied in two practice courses on real word biomedical datasets.

Learning outcomes

After passing this course successfully students are able to ...

  • give an overview of bioinformatics fields of application and associated theoretical background
  • solve selected bioinformatics tasks independently

Course contents

  • Overview of bioinformatics areas and the theoretical background as well as used methods
  • Biological databases
  • Background of high-throughput Omics experiments
  • Analysis of high-throughput Omics datasets
  • Bioinformatics analysis of with selected examples during practice courses

Prerequisites

- Basics in computer handling - Basics in statistics - Basics in biology, medicine

Literature

  • .

Assessment methods

  • Writte exam at the end
  • Evaluation of practice course protocols
  • Exam and protocols account for 50% of the final degree each and both have to be positively completed

Anmerkungen

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Molecular Biochemistry and Cell Biology (MBC)
English / ILV
6.00
2.50

Course description

The students obtain detailed knowledge of fundamental molecular and cellular processes in eukaryotic cells and understand their relevance for tissue engineering and regenerative medicine.

Methodology

- Lectures- Distance learning (eLearning)

Learning outcomes

After passing this course successfully students are able to ...

  • give a detailed overview of the essential genetic mechanisms of the cell (replication, transcription, translation, regulation of gene expression, repair, and recombination)
  • specify cellular components (membranes, cytoskeleton, intracellular compartments), protein sorting, and intracellular membrane traffic, and explicate basic mechanisms underlying cell communication, cell cycle, and cell division
  • update this knowledge and integrate it into the concepts of tissue engineering and regenerative medicine with relevant publications
  • solve straightforward, research-based thought problems, related to the above mentioned contents

Course contents

  • DNA structure and functionality
  • regulation of gene expression
  • internal organisation of the cell

Prerequisites

basic knowledge of biochemistry and molecular biology

Literature

  • Alberts, Bruce et al., (2014): Molecular Biology of the Cell, Garland Science

Assessment methods

  • successfully complete the eLearning elements
  • active participation
  • final written exam
Laboratory Work in Teams 1 (iM11)
English / iMod
7.00
-
Project Laboratory 1 (PL1)
English / PRJ
6.00
3.00

Course description

Groups of approximately three students work independently on different practical methods and their theoretical backgrounds relevant for Tissue Engineering and Regenerative Medicine.

Methodology

Every group of students is supervised by a lecturer, who guides them throughout the semester. In the lab students are supervised by the members of the Competence Team "Tissue Engineering Bioreactors".

Learning outcomes

After passing this course successfully students are able to ...

  • perform basic steps in cell culture (cell seeding and counting, growth curve, cell stainings) and 2 (out of 4) techniques relevant in tissue engineering (preparation of silk scaffolds, RT-PCR, Western blotting, primary cell culture)
  • identify relevant literature, write a scientific introduction and develop and implement a working plan on a given topic
  • evaluate and interpret their scientific results, summarize them in a written report (IMRAD-structure) and present them to supervisors, lecturers and students
  • keep records on their laboratory experiments
  • approach and solve scientific problems within a team

Course contents

  • Scientific literature research and writing of a scientific introduction
  • Planning experiments
  • Writing a scientific report
  • Conducting experiments in the lab
  • Presentation of the obtained data in front of an auditorium (consisting of the other groups and all supervising lecturers)

Prerequisites

Basic knowledge about cell and tissue biology as well as corresponding lab experience.

Literature

  • current scientific literature

Assessment methods

  • Exams
  • Documentation of lab work (lab book)<
  • Presentation of data
  • Writing reports
  • Performance in the lab
  • Documentation of the whole project
Team Management (TEA)
English / SE
1.00
0.50

Course description

In the course the students get to know main principles of leading teams.

Learning outcomes

After passing this course successfully students are able to ...

  • explain the role of leadership in the different stages of team development (for example by Tuckman) and to derive relevant leading actions (for example directive leadership in the forming phase).
  • diagnose dynamics in project teams using models (for example Rank Dynamics, Drama Triangle, TZI) and to develop and argue case-related concrete opportunities for activities (for example delegation of responsibilty, critical discussion).

Course contents

  • Leadership functions and tasks
  • Leadership tools in project teams
  • Role conflicts "colleague" and "project leader"
  • Leading without formal power and competence
  • Overview of theories to group dynamics
  • Conflicts and difficult situations in leading project teams

Literature

  • Berkun, S. (2005): The Art of Project Management, Sebastopol: O’Reilly Media
  • Cronenbroeck, W. (2008): Projektmanagement, Berlin: Cornelsen Verlag [bilingual book: in English and German]
  • Haeske, U. (2008): Teamentwicklung, Berlin: Cornelsen Verlag, [bilingual book: in English and German]

Assessment methods

  • An individual reflection paper about the group processes encountered in the semester and how the knowledge about group dynamic processes and communication models was applied.

Anmerkungen

The course also includes team coaching for the teams in the course Project Laboratory 1.

Protein Chemistry (iM15)
English / iMod
4.00
-
Protein Chemistry (PRO)
English / ILV
4.00
3.00

Course description

The students obtain knowledge about structure, function as well as analytics of proteins. Additionally, selected therapeutics based on proteins are discussed.

Methodology

- PowerPoint presentations- Workshops- Seminar talks

Learning outcomes

After passing this course successfully students are able to ...

  • explain the composition and chemical structure of proteins and name modifications and their functions
  • name the most important methods for the chemical analysis of proteins and explain their basic principles
  • explain the basic mechanisms of protein function
  • explain interactions between proteins using examples

Course contents

  • Chemical structure of proteins
  • Post-translational modifications
  • Bioinformatics
  • Protein quantification
  • Separation techniques
  • Proteomics
  • Protein function
  • Enzymes, antibodies, structural proteins
  • Protein therapeutics

Prerequisites

- Basics of organic and analytical chemistry- Basics of cell biology

Literature

  • Behme, Stefan (2015): Manufacturing of Pharmaceutical Proteins, Wiley-Blackwell
  • Lottspeich, Friedrich / Engels, Joachim W (2013): Bioanalytik, Spektrum Akademischer Verlag
  • Petsko, Gregory A / Ringe, Dagmar (2008): Protein Structure and Function, Oxford University Press
  • Stryer, Lubert (2015): Biochemistry, W. H. Freeman

Assessment methods

  • Active participation
  • Seminar talk
  • Written exam
Tissue Engineering (kM14)
English / kMod
8.00
-
Biomaterials in Tissue Engineering (BMT)
English / ILV
2.00
1.00

Course description

The students obtain knowledge medical applications of biomaterials as well as about basic concepts regarding design and mechanical properties of selected natural and synthetic biomaterials. Topics from current research projects of the UAS Tech are explained and discussed.

Methodology

- Lecture/Presentation- Discussion

Learning outcomes

After passing this course successfully students are able to ...

  • describe the basic techniques to manufacture scaffolds from raw biomaterials and explain the different prerequisites for the biomaterials.
  • explain nature design concepts in the biomaterials field.
  • differentiate biomaterials regarding their properties and assess their usage in a specific application.
  • describe the most common techniques to test cell biocompatibility of biomaterials and apply them on different biomaterials.
  • correlate the protein structure of a biomaterial with its properties as a biomaterial.

Course contents

  • Elements of biomaterials
  • Self-assembly and growth
  • Mechanical concepts in biomaterials
  • Different protein fibers: collagen, silk, keratin
  • Methods for the determination of biocompatibility
  • Soft tissue - skin
  • Cartilage
  • Biological composite materials e.g. fibers
  • Hierarchical design bone, wound care und suture materials, vascular implants, biomimetic and bio-inspired materials

Prerequisites

Basics of chemistry and protein chemistry

Literature

  • Gordana Vunjak-Novakovic, R. Ian Freshney (2006): Culture of Cells for Tissue Engineering, Wiley
  • Ulrich Meyer, Thomas Meyer, Jörg Handschel, Hans Peter Wiesmann (2009): Fundamentals of Tissue Engineering and Regenerative Medicine, Springer
  • Relevant publications will be provided via CIS

Assessment methods

  • Final exam
Tissue Engineering for Regenerative Medicine (TER)
English / ILV
4.00
2.00

Course description

In the first part of the course the most important tools used in tissue engineering (e.g. cells, scaffolds, cell-cell communication,…) are discussed. After an intermediate exam, the second part of the course at the one hand deals with tissue engineering concepts and strategies of different tissue types (e.g. cartilage, bone,…), on the other hand with the application of cells in regenerative medicine. Course contents are deepened by activities of the students during the course.

Methodology

- Lectures- Distance learning- Team work and presentations of the students- Guest lectures

Learning outcomes

After passing this course successfully students are able to ...

  • name different cell types, explain their characteristics and select them for different applications in tissue engineering
  • list different methods for scaffold production and explain their advantages and disadvantages for application in tissue engineering
  • describe different methods for cell differentiation and select suitable detection methods for cell differentiation
  • describe the correlation between different tissue components (cells, extracellular matrix,…) and define differences between selected tissue types
  • describe and compare different tissue engineering concepts using examples
  • give an overview about the application of cells for regenerative medicine, name examples and explain advantages and disadvantages of stem cells as therapeutics

Course contents

  • Components used in tissue engineering
  • Primary cells, cell lines and immortalization of cells
  • Extracellular matrix
  • Communication between cells
  • First steps of animal development
  • Cell differentiation and stem cells
  • Scaffolds for tissue engineering
  • Tissue engineering of bones and cartilage
  • Skin tissue engineering and application
  • Heart valves tissue engineering
  • Cell therapy in regenerative medicine
  • Immunomodulation of mesenchymal stem cell
  • Biofabrication

Prerequisites

- basic knowledge in cell biology- basic knowledge in biochemistry

Literature

  • Gordana Vunjak-Novakovic, R. Ian Freshney (2006): Culture of Cells for Tissue Engineering, Wiley
  • Ulrich Meyer, Thomas Meyer, Jörg Handschel, Hans Peter Wiesmann (2009): Fundamentals of Tissue Engineering and Regenerative Medicine, Springer
  • Relevant literature (e.g. papers) will be provided

Assessment methods

  • Collaboration during lessons
  • Distance learning
  • Presentations
  • Intermediate written exam
  • Final written exam

2. Semester

Name ECTS
SWS
Bioreactors and Biotechnology (kM23)
English / kMod
7.00
-
Bioreactors in Tissue Engineering (BRTE)
English / ILV
4.00
2.00
Biotechnology (BT)
English / ILV
3.00
2.00
From DNA to Protein 2 (kM22)
English / kMod
9.00
-
Gene Regulation and Signal Transduction (GRST)
English / VO
3.00
2.00
Methods in Cellbiology (incl. Lab) (MIC)
English / ILV
6.00
2.00
Laboratory Work in Teams 2 (iM21)
English / iMod
7.00
-
Project Laboratory 2 (PRL2)
English / PRJ
6.00
3.00
Project Management and Leadership (PML)
English / SE
1.00
0.50
Scientific Research Design, Evaluation and Communication (kM24)
English / kMod
7.00
-
Ethics in Engineering and Medicine (EEM)
English / SE
1.00
1.00
Projectmanagement for (Bio)Pharmaceutical Products (PPP)
English / SE
2.00
2.00
Study Design and Biostatistics (SDB)
English / VO
3.00
2.00
Writing Scientific English (WSE)
English / SE
1.00
1.00

3. Semester

Name ECTS
SWS
Economic & Legal Issues and Professional Communication 2 (kM34)
English / kMod
7.00
-
Case Studies in Pharmaceutical Industries (CSPI)
English / SE
2.00
2.00

Course description

The course provides insights into the daily practice of management in pharmaceutical companies to the students. Subjects are based on the four management tasks Planning, Organizing, Leading and Controlling, as covered in the course Corporate Management (COM/MTE1). Also Pharma Marketing subjects as discussed in the course Economics & Marketing (EMA/MTE3) will be studied in practical cases.

Methodology

- Solutions of case studies in group work as well presenting and discussing these with all members of the class- Roleplays of practical situations of pharma management- Partly short theoretical introductions with lectures and powerpoint charts- Case master solutions will be provided

Learning outcomes

After passing this course successfully students are able to ...

  • analyze and evaluate financial information of a pharmaceutical company (Financial Statements, Planning etc.)
  • develop suitable measures of crisis management in a pharmaceutical company (Action Plan, Communication, Savings Programs etc.)
  • conduct analyses to prepare a decision about a merger of two pharma companies
  • hold difficult meetings with direct reports in daily operations of a pharmaceutical business
  • recognize the importance of company politics in a global pharmaceutical enterprise and develop according ways to behave in this environment
  • develop options for a good cross-functional cooperation in a global pharmaceutical company
  • evaluate advantages and disadvantages of various forms of communication in a company
  • develop suitable ways to motivate employees in a company, particularly top talents

Course contents

  • Case study solution methodology, crisis management, project management, financial analysis, communication, business evaluation, talent management, investment analysis, motivation of employees, asset management, financing resources, entrepreneurship, audits, pharmaceutical sales call, change management, compliance, negotiations and meetings.

Prerequisites

Course Corporate Management (COM/MTE1)

Literature

  • Stephen P. Robbins, David A. DeCenzo, Mary CoulterFundamentals of ManagementPearson Education, 2014, 9th Global EditionISBN-10: 1292056541ISBN-13: 978-1292056548

Assessment methods

  • Paper with case study – weight 50%
  • Active Class Input (Groups, Plenum) – weight 50%. Students must achieve at least 50% in both assessment elements
Economics and Marketing (EM)
English / VO
3.00
2.00
Management for Quality in Biomedicine (MQB)
English / ILV
2.00
1.00

Course description

In the first part of the course, students are given an introduction to quality management systems (QMS) acc. to ISO 9001 and 13485.The second part centers on topics relevant for pharmaceutical industry: GMP, qualification and validation.

Learning outcomes

After passing this course successfully students are able to ...

  • draft SOPs
  • check the structure of a QMS
  • set up a validation concept for an analytical method, a process or an equipment and to present it
  • to apply FMEA for risk assessment independently

Course contents

  • Principles of Quality Management Systems acc. to ISO 9001 and 13485GMP, GDP, GLP; qualification of equipment; validation of methods and processes

Literature

  • MHRA: Rules and Guidance for Pharmaceutical Manufacturers and Distributors; 2014

Assessment methods

  • Course immanent assessment method and end exam
Methods of Scientific Research (iM35)
English / iMod
8.00
-
Methods of Scientific Research (MSR)
English / PRJ
8.00
0.00
Nanotechnologies (iM32)
English / iMod
4.00
-
Nanotechnologies (NT)
English / ILV
4.00
2.00

Course description

Overview of the nanobiotechnological application potential as well as deepening of several sub-topics.

Methodology

- Lectures- Presentations- Self-dependent working on exercises- Videos

Learning outcomes

After passing this course successfully students are able to ...

  • define the concept of thermal energy and relate such concept to understand life-time interactions in biological systems.
  • describe the principle of electron microscopy (EM) and atomic force microscopy (AFM) for the elucidation of the nanostructure of biomaterials as well as to measure molecular forces between molecules (AFM).
  • explain molecular modifications for synthetic biointerfaces that control interactions with molecules in biological fluids
  • describe and evaluate the colloidal aspects of current nanoscale drug delivery systems.
  • explain the term biosensor and describe the physical background of optical biosensors (focus on plasmonic properties) including their application in bioassays
  • explain different microfabrication methods and microfluidic components, describe the physical principles regarding fluids on a microscale and give application examples for cell analysis based on lab-on-chips
  • explain the biochemical principles behind binding events relevant for microarrays and give specific examples in which fields microarrays are used.
  • describe the biochemical principles of molecular nanomotors based on proteins and nucleic acids and give examples of the application potential of such structures

Course contents

  • Biosensors
  • Functional biointerfaces
  • Biomembranes
  • Characterization of nanostructures
  • Drug delivery
  • Lithography and miniaturization
  • Microfluidics
  • Lab-on-a-chip application
  • Molecular recognition and interaction
  • Microarrays
  • Molecular nanomotors

Prerequisites

Biochemistry, basics in physics

Literature

  • Nanobiotechnology II, Wiley-VCH by Mirkin et al.
  • Biomedical Nanostructures, Wiley by Consalves et al.
  • Wissenschaftliche Literatur aus der LV
  • Matthew A. Cooper, Label-Free Biosensors, Cambridge University Press, 2009.
  • F. S. Ligler (editor), Optical Biosensors: Present and Future, Elsevier, 2002
  • B. E. A. Saleh, M. C. Teich, Fundamentals of Photonics, John Wiley & Sons, 1991.

Assessment methods

  • Collaboration during the lectures
  • Presentations
  • Self-dependent solution of exercises
  • Final exam
Regenerative Medicine (kM33)
English / kMod
5.00
-
Current Problems in Regenerative Medicine (CPRM)
English / SE
1.00
1.00
Stem Cells in Regenerative Medicine (SCRM)
English / ILV
4.00
2.00
Tissue Engineering 2 (kM31)
English / kMod
6.00
-
Advanced Immunology and Vascular Tissue Engineering (AIVTE)
English / ILV
4.00
2.00

Course description

This lecture helps to extend and deepen the knowledge of immunological processes in connection to tissue engineering. Furthermore, basic knowledge in vascular biology will be taught. This is necessary to understand the principles of vascular tissue engineering

Methodology

- Lecture- Presentations- Group puzzle

Learning outcomes

After passing this course successfully students are able to ...

  • apply complex immunological processes to tissue engineering
  • describe the cascades of the wound healing process
  • describe the processes of formation of blood and lymphatic vessels
  • recapitulate the principles of vascular tissue engineering

Course contents

  • Wound healing
  • Inflammation
  • Complement system
  • Transplantation
  • Graft rejection
  • Angiogenesis
  • Lymphangiogenesis
  • Endothelial cells in research
  • Examples of Vascular tissue engineering

Prerequisites

Basic knowledge of immunology

Literature

  • Current literature (papers) provided during the lecture

Assessment methods

  • Group puzzle
  • Collaboration
  • Paper presentation
  • Examination (the grades of the exam is the basis, up- or down grading is possible by the other assessment criteria)
Biochemical Research Papers (BR)
English / ILV
1.00
1.00

Course description

In this course the contents and structure of scientific publications and grants will be analyzed according to different criteria and publishing of a paper will be demonstrated. Furthermore, students present and discuss selected scientific papers.

Methodology

Lectures, e-learing, discussions, presentations

Learning outcomes

After passing this course successfully students are able to ...

  • analyse and present scientific papers
  • specify quality criteria of scientific work and include them in own papers (ie: Master thesis)
  • cite correctly
  • write scientific texts

Course contents

  • Structure of scientific publications
  • critical assessment of scientifc publications („good“ versus „bad“ papers) according to defined criteria
  • review process
  • presentations of scientific publications according to selected examples

Prerequisites

knowledge in literature research writing a scientific thesis (including an abstract)

Literature

  • slides, moodle-tool and recent papers

Assessment methods

  • Course immanent assessment method (e-learning tasks (40%) und presentations (60%))

Anmerkungen

The e-learning courses can be passed at the FH Technikum or at home. The tool is only provided in a certain time of the course. Advantage at the FH: lecturer is present for questions.

Project Laboratory 3 (PL3)
English / PRJ
1.00
0.50

4. Semester

Name ECTS
SWS
Master's Thesis (iM41)
English / iMod
30.00
-
Master's Thesis (MT)
English / BE
28.00
0.00
Seminar for Degree Candidates (SDC)
English / SE
2.00
0.25