NeoNatSim (Advanced Neonatal Breathing Simulation Using Animal Lung Models)

NeoNatSim is an innovative project of University of Applied Sciences Technikum Wien in collaboration with Medical University of Vienna focused on advancing neonatal respiratory simulation by integrating animal lungs (such as from rabbits and sheep) with a modified version of the existing xPULM lung simulator. Tailored to meet the specifications provided by clinical partners, this project aims to replicate the intricate mechanics of newborn breathing.

Simulating paediatric lung functionality poses unique challenges compared to adult models—newborns exhibit extremely low tidal volumes, high breathing frequencies, and reduced overall lung volumes, all of which demand a high level of precision during data recording and system calibration. NeoNatSim addresses these challenges by adapting the xPULM framework to incorporate specialized sensors and high-resolution data logging, ensuring that even the subtle dynamics of neonatal respiration are captured accurately.

Key modifications include the integration of anatomically accurate airway replicas and the use of ex vivo animal lungs that reliably mimic the biomechanical properties of neonatal lung tissue. By recreating realistic spontaneous breathing patterns and response variations under different respiratory loads, NeoNatSim provides a reproducible and clinically relevant simulation environment. Ultimately, this system is expected to facilitate enhanced research in neonatal respiratory care, support the training of medical professionals, and contribute to optimizing ventilation strategies for the most vulnerable patients.